Virendra Singh Raghuvanshi, Sasmita Panda


Aims and objective :To compare combinations of  Propofol-Ketamine and Propofol-Fentanyl for total intravenous anesthesia in short surgical cases in pediatric patients. The study also  compared  recovery characteristics and  the incidence of side effects / complications in the groups.

Methodology: The patients were randomly divided into two groups depending upon the drug combination used for Total Intravenous Anaesthesia.

Group I : 30 patients were given i.v. Ketamine followed by Propofol.

Group II: 30 patients were given i.v. Fentanyl followed by Propofol

Recovery characteristics were compared  and  the incidence of side effects and complications in two groups were noted.

Results: The pulse rate  and blood pressure remained near to preinduction value in group I, while in group II  these values  decreased. After induction RR increased in group I but decreased  in group II at 1,3%5 min after induction.None of the patients in both groups were observed to have nausea, vomiting and respiratory depression. . A significant no. of the patients in group II were observed to have either pain on injection site or restlessness.

Conclusion: Propofol-Ketamine and Propofol-Fentanyl combinations provide satisfactory surgical conditions for minor surgical procedures in paediatric patients, but the Propofol-Ketamine combination gives better hemodynamic stability and less restlessness during induction and maintenance of anaesthesia. 


Propofol,Ketamine ,Fentanyl , Hemodynamic stability

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Krauss B, Green SM. Sedation and analgesia for procedures in children. New England Journal of Medicine. 2000 Mar 30;342(13):938-45.

McDowall RH, Scher CS, Barst SM. Total intravenous anesthesia for children undergoing brief diagnostic or therapeutic procedures. Journal of clinical anesthesia. 1995 Jun 1;7(4):273-80.

Aydin Erden I, Gulsun Pamuk A, Akinci SB, Koseoglu A, Aypar U. Comparison of propofol‐fentanyl with propofol‐fentanyl‐ketamine combination in pediatric patients undergoing interventional radiology procedures. Pediatric Anesthesia. 2009 May 1;19(5):500-6.

Tosun Z, Esmaoglu A, Coruh A. Propofol–ketamine vs propofol–fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes. Pediatric Anesthesia. 2008 Jan 1;18(1):43-7.

Khutia SK, Mandal MC, Das S, Basu SR. Intravenous infusion of ketamine-propofol can be an alternative to intravenous infusion of fentanyl-propofol for deep sedation and analgesia in paediatric patients undergoing emergency short surgical procedures. Indian journal of anaesthesia. 2012 Mar;56(2):145.

Singh R, Batra YK, Bharti N, Panda NB. Comparison of propofol versus propofol‐ketamine combination for sedation during spinal anesthesia in children: randomized clinical trial of efficacy and safety. Pediatric Anesthesia. 2010 May 1;20(5):439-44.

Alletag MJ, Auerbach MA, Baum CR. Ketamine, propofol, and ketofol use for pediatric sedation. Pediatric emergency care. 2012 Dec 1;28(12):1391-5

Weatherall A, Venclovas R. Experience with a propofol–ketamine mixture for sedation during pediatric orthopedic surgery. Pediatric Anesthesia. 2010 Nov 1;20(11):1009-16.

Goel S, Bhardwaj N, Jain K. Efficacy of ketamine and midazolam as co‐induction agents with propofol for laryngeal mask insertion in children. Pediatric Anesthesia. 2008 Jul 1;18(7):628-34.

Rai K, Hegde A, Goel K. Sedation in uncooperative children undergoing dental procedures: a comparative evaluation of midazolam, propofol and ketamine. Journal of Clinical Pediatric Dentistry. 2007 Sep 1;32(1):1-4.


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