Saptarshi Banerjee, Subir Pal


Gallbladder cancer is the most common malignancy of the biliary tract. Various epidemiological reviews have reported that incidence of Gall Bladder Cancer varies geographically, with highest incidence in Chile. Gall bladder cancer is a common cancer in the northern and Northeastern States of India and rare in southern part.Females are affected 2-6 times more than male. Cholelithiasis is one of the major risk factors associated with gall bladder carcinoma. Objective of this study is to find the epidemiological pattern of carcinoma gall bladder attending to a tertiary centre, during a span of 2 years. This study included all patients with carcinoma gall bladder attending to the department of radiotherapy, of a multispeciality hospital, in Kolkata, West Bengal, India, during the period from June 2015 to May 2017. The male-female variation, age distribution, main symptoms, presence of associated gall stones, mode of diagnosis (incidental/ non incidental), stage at diagnosis, and performance status of the patients were recorded. During the 2 years duration, from June 2015 to May 2017, total 177 patients of gall bladder carcinomas attended our department. Maximum patients are of fifth and sixth decade. Among them 136 are female and 41 are male. Male female ratio is 1: 3.32. Among these 177 patients 169 patients presented with co-existent gall stone and 8 patients without stone. So the percentage of co-existent gall stone disease in gall bladder cancers in this study is 95.48%. Maximum patients presented with abdominal pain (98) and considerable amount with jaundice (49). 10.7% patients were diagnosed incidentally during or after cholecystectomy for gall stone. Maximum patients of gall bladder carcinoma were in diagnosed in advanced stage.


gall bladder carcinoma, epidemiology, gall stone

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Lazcano-Ponce EC, Miquel JF, Muñoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA: Cancer J Clin 2001. 2001;51(6):349–364. [PubMed]

Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 1992;70:1493–1497. [PubMed]

Wistuba II, Gazdar AF. Gallbladder cancer: lessons from a rare tumour. Nat Rev Cancer. 2004;4:695–706. [PubMed]

Lai CH, Lau WY. Gallbladder cancer: a comprehensive review. Surgeon. 2008;6:101–110. [PubMed]

Andia M, Ferreccio C, Gederlini A. Gallbladder cancer: trend and risk distribution in Chile. Rev Med Chile. 2006;134:565–574. [PubMed]

Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118(7):1591–1602. [PubMed]

Nandakumar A, Gupta PC, Gangadharan P, Visweswara RN, Parkin DM. Geographic pathology revisited: Development of an atlas of cancer in India. Int J Cancer. 2005;116:740–54. [PubMed]

Konstantinidis IT, Deshpande V, Genevay M, et al. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg. 2009;144(5):441–447. [PubMed]

S. P. Kaushik, “Current perspectives in gallbladder carcinoma,” Journal of Gastroenterology and Hepatology, vol. 16, no. 8, pp. 848–854, 2001.

T. Rustagi and C. A. Dasanu, “Risk factors for gallbladder cancer and cholangiocarcinoma: similarities, differences and updates,” Journal of Gastrointestinal Cancer, vol. 43, no. 2, pp. 137–147, 2012.

Shaffer EA. Gallbladder cancer: the basics. Gastroenterol Hepatol (N Y) 2008;4:737–741. [PMC free article] [PubMed]

Pilgrim CH, Groeschl RT, Christians KK, Gamblin TC. Modern perspectives on factors predisposing to the development of gallbladder cancer. HPB (Oxford) 2013;15:839–844. [PMC free article] [PubMed]

Iyer P, Barreto SG, Sahoo B, Chandrani P, Ramadwar MR, Shrikhande SV, Dutt A. Non-typhoidal Salmonella DNA traces in gallbladder cancer. Infect Agent Cancer. 2016;11:12. [PMC free article] [PubMed]

Zatonski WA, Lowenfels AB, Boyle P, et al. Epidemiologic aspects of gallbladder cancer: a case-control study of the SEARCH Program of the International Agency for Research on Cancer. J Natl Cancer Inst. 1997;89(15):1132–1138. [PubMed]

Piehler JM, Crichlow RW. Primary carcinoma of the gallbladder. Surg Gynecol Obstet. 1978;147:929. [PubMed]


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