Navin Agrawal, Mannu Vikram, Iccha Kumar Maharjan, Vimmi Singh, Sushmita Shrestha, Ashish Shrestha


Introduction: The problem that dentistry has been facing is to integrate the new materials with potential of healing forming hard tissue during dental treatment. Objective: Clinical and radiographic assessment of reparative dentin formation using Tricalcium Silicate (Biodentine), MTA and Ca(OH)as pulp capping agents. Methods: 114 asymptomatic carious teeth involving inner third dentine were treated randomly with one of the pulp capping agents and Fuji IX GIC. They were assessed in 2nd and 6th month with final restoration (composite/amalgam) in 6 month if asymptomatic. Results: The overall analysis indicated few failure in the Biodentine group (7.9%; n=3) and MTA group (2.6%; n=1) than in the Ca(OH)2 group (0%; n=0).On comparison between Biodentine and MTA using Chi Square Fisher’s Exact Test (=.615), revealed no significant difference between the group.  Conclusion: This study provided evidence to use Biodentine as an indirect pulp-capping agent as compared with MTA and Ca(OH)2.


Pulp Capping, MTA, Biodentine, Ca(OH)₂

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Aguilar P, Linsuwanont P (2011). Vital pulp therapy in vital permanent teeth with cariously

exposed pulp: a systematic review. J Endod, 37, 581–7.

Alicja Nowicka, Mariusz Lipski, Miroslaw Parafiniuk, et al., (2013). Response of Human

Dental Pulp Capped with Biodentine and Mineral Trioxide Aggregate. J Endod, 39, 743–747.

Avina Paranjpe, Hai Zhang, and James D. Johnson (2010). Effects of Mineral Trioxide

Aggregate on Human Dental Pulp Cells after Pulp-capping Procedures. J Endod, 36, 1042–

Cox CF, Sǖbay RK, Ostro E, et al., (1996). Tunnel defects in dentin bridges: their formation

following direct pulp capping. Oper Dent 1996; 21:4–11.

Dimitrios Tziafas (2010). Dentinogenic potential of the dental pulp: facts and hypotheses.

Endodontic Topics, 17, 42–64.

Claudia Brizuela, Andrea Ormeño, Carolina Cabrera, et al., (2017). Direct Pulp Capping with

Calcium Hydroxide, Mineral Trioxide Aggregate, and Biodentine in Permanent Young Teeth

with Caries: A Randomized Clinical Trial. J Endod, 43, 1776-1780.

Eskandarizadeh A, Shahpasandzadeh MH, Shahpasandzadeh M, et al., (2011). A comparative

study on dental pulp response to calcium hydroxide, white and grey mineral trioxide

aggregate as pulp capping agents. J Conserv Dent, 14, 351–5.

Koubi G, Colon P, Franquin JC, et al., (2013). Clinical evaluation of the performance and safety

of a new dentine substitute, Biodentine, in the restoration of posterior teeth: a prospective

study. Clin Oral Investig, 17, 243–9.

Marjorie Zanini, Jean Michel Sautier, Ariane Berdal, et al., (2012). Biodentine Induces

Immortalized Murine Pulp Cell Differentiation into Odontoblast-like Cells and Stimulates

Biomineralization. J Endod, 38, 1220–1226.

Min KS, Park HJ, Lee SK, et al., (2008). Effect of mineral trioxide aggregate on dentin bridge

formation and expression of dentin sialoprotein and heme oxygenase-1 in human dental pulp.

J Endod, 34, 666–70.

Paul R. Cooper, Yusuke Takahashi, Lee W. Graham, et al., (2010). Inflammation–regeneration

interplay in the dentine–pulp complex. Journal of Dentistry, 38, 687–697.

Seale NS, Glickman GN (2008). Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists. J Endod, 34, S57–61.

T.J. Hilton, J.L. Ferracane, L. Mancl (2013). Comparison of CaOH with MTA for Direct Pulp

Capping: A PBRN Randomized Clinical Trial. J Dent Res, 92, S16-22.

Xiaohong Wanga, Hongchen Suna, Jiang Chang (2008). Characterization of Ca3SiO5/CaCl2 composite cement for dental application. Dental Materials, 24, 74–82.


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