Muktanjalee Deka, Manisha Salvi


Sinonasal  Teratocarcinosarcoma  (SNTCS)  is  a  very  unusual  and  aggressive  neoplasm  characterized   by  a  histologic  combination  of  malignant  teratoma  and  carcinosarcoma  with  a  triphasic  growth   pattern  including  epithelial,  mesenchymal  and  primitive  neuroectodermal  components.  This  neoplasm is  mostly  seen  in  adults  with  a  mean  age  of  55  years.  Here,  we  report  a  SNTCS  in  a  17  year old  male  presented  with  left  sided  nasal  mass  for  last  6  months  which  was  surgically  resected. Histopathology  and  immunohistochemistry  confirmed  the  diagnosis  of  sinonasal  teratocarcinosarcoma. SNTCS  is  highly  malignant  and  locally  aggressive.  About  60%  patients  do  not  survive  beyond  3 years.  Total  excision  and  extensive  sampling  are  necessary  to  reach  the  diagnosis.  Early  diagnosis and  management  can  give  a  better  prognosis


malignant teratoma, carcinosarcoma, teratocarcinosarcoma

Full Text:



Carrizo F, Pineda-Daboin K, Neto AG, Luna MA. Pharyngeal teratocarcinosarcoma: Review of literature and report of two cases. Ann Diagn Pathol. 2006;10:339-42.

Rotenberg B, El- Hakim H, Lodha B, MacCormick A, Ngan BY, Forte V. Nasopharyngeal teratocarcinosarcoma. Int J Pediatr Otol Rhinol Aryngol. 2002;62:159-64.

Crazzolara R, Puelacher W, Ninkovic M, Zelger B, Buchberger W, Meister B, et al. Teratocarcinosarcoma of the oral cavity. Pediatr Blood Cancer. 2004;43:687-91.

Shanmugaratnam K, Kunaratnam N, Chia KB, Chiang GS, Sinniah R. Teratoid carcinosarcoma of the paranasal sinuses. Pathology. 1983;15:413-9.

Heffner DK, Hyams VJ. Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses a clinicopathologic study of 20 cases. Cancer. 1984;53:2140-54.

Cardesa A, Alos L. Franchi A: Nasal cavity and paranasal sinuses. In: Cardesa A, Slootweg PJ, editors. Pathology of the Head and Neck. Berlin, Heidelberg: Springer; 2006. pp 50-64.

Agrawal N, Chintagumpala M, Hicks J, Eldin K, Paulino AC. Sinonasal teratocarcinosarcoma in an adolescent male. J Pediatr Hematol Oncol. 2012;34:e304-7.

Wei S, Caroll W, Lazenby A, Bell W, Lopez R, Said-Al-Naief N. Sinonasal teratocarcinosarcoma: Report of a case with review of literature and treatment outcome. Ann Diagn Pathol. 2008;12:415-25.

Su YY, Friedman M, Huang CC, Wilson M, Lin HC. Sinonasal teratocarcinosarcoma. Am J Otolaryngol. 2010;31:300-3.

Thomas J, Adegboyega P, Iloabachie K, Mooring JW, Lian T. Sinonasal teratocarcinosarcoma with yolk sac elements: a neoplasm of somatic or germ cell origin? Ann Diagn Pathol. 2011;15:135-9.

Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. 3rd ed. Lyon: International Agency for Research on Cancer;2005.p. 76-7.


  • There are currently no refbacks.