ASSESSMENT OF OXIDATIVE STRESS MARKERS AND LIPOPROTEIN(A) IN PATIENTS WITH STROKE IN A TERTIARY CARE HOSPITAL

Syed Tousif Ahmad Rizvi, Mohd Aslam, M Mobarak Hossain, M Shoaib Zaheer

Abstract


Objective:To study the status of oxidative stress markers such as Superoxide Dismutase(SOD), Glutathione
Peroxidase(GPx), product of lipid peroxidation Malondialdehyde(MDA) and serum Lipoprotein(a) concentrations
in cases i.e. stroke subjects.
Materials and Methods: A total of 28 subjects, fourteen (14) cases and fourteen (14) controls were selected as per convenience keeping in
mind the logistics and time constraints.Patient admitted to medicine wards with established diagnosis of stroke were taken as cases. The
diagnosis was established on the basis of history, clinical examination and imaging studies. While age and sex matched controls were
randomly selected from Medicine OPD. Unpaired T- test was used for statistical signi􀃶cance. A value less than 0.05 was considered as
signi􀃶cant.
Results: Glutathione peroxidase(GPx) levels were lower in cases than in controls (P <0.05).Superoxide dismutase(SOD) levels were very low
in cases than in controls(P <0.001).Malondialdehyde(MDA) levels were higher in cases than in controls but relationship was not found to be
signi􀃶cant(p>0.05). Lipoprotein (a) levels were very high in cases than in controls(P <0.001).
Conclusion:The present study reveals reduced GPx and SOD while MDA and Lipoprotein(a) levels were high in stroke subjects in 􀃶rst 24
hours.This indicates prominent role ofreduced GPx and SOD in increase of oxidative stress during early ischaemic period.Further it was also
found that increased Lipoprotein(a) in early ischaemic period is associated with higher risk of stroke. Measurement of these biomarkers can
quantify the risk of stroke.


Keywords


Oxidative stress,Lipid peroxidation,Lipoprotein(a), Stroke

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