Tejas Rane, Virendra C. Patil, Akshay Kale


Rhino-cerebral mucormycosis is a rare, invasive fungal infection caused by fungi of the order Mucorale and class of
mucormycets. It is one of the diseases that remain poorly understood with high mortality rate. Presently, the triad of
clinician's awareness prompt initiation of treatment and timely surgical intervention is the effective way of managing the disease. We report
a case of 52 year old female with diabetes mellitus with history of fever, peri-orbital oedema, ptosis, opthalmoplegia and ulcers in hard palate.
Patient was diagnosed to have Rhino-cerebral mucormycosis with cavernous sinus extension. She was treated with intravenous
Amphotericin B, insulin, Functional endoscopic sinus surgery (FESS) and debridement. She was given intravenous antifungal therapy
followed by oral antifungal. Patient showed signi􀃶cant improvement.


Rhino-cerebral mucormycosis, Diabetes mellitus, opthalmoplegia, Amphotericin B

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Nithyanandam S, Jacob MS, Battu RR et al Rhino-orbito-cerebral mucormycosis. A retrospective analysis of clinical features and treatment outcomes. Indian journal of ophthalmology.2003.51:231-6.

Cheng VC, Chen JH, Wong SC, et al. Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2016; 62:714-21

Yanagisawa E, Friedman S, Kundargi RS et al: Rhinocerebralphycomycosis. Laryngoscope 1977; 87: 1319-35.

Ferguson BJ. Mucormycosis of the nose and the paranasal sinuses. Otolaryngol Clin N Am 2000; 33: 349–65.

Yousem DM, Galetta LS et al finding inrhino-cerebralmucormycosis. J Computer AssistTomography 2001; 13:878–82.

Hosseini,Borghei.Rhinocereberalmucormycosis:pathwaysof spread.Eur Arch Otorhinolaryngoly. 2005;262:932-8.

Bhansali A, Bhadada S, Sharma A etal. Presentation and outcomeofrhino-orbital-cerebralmucormycosis in patients with diabetes.Post Grad Med Journal 2004; 80: 670-4.

Spellberg B, Ibrahim AS, Chin-Hong PV, et al. The DeferasiroxAmBisomeTherapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. The Journal of antimicrobial chemotherapy2012; 67:715-22.

Soman R, Gupta N et al. Deferasirox in mucormycosis: hopefully, not defeated. The Journal of antimicrobial chemotherapy2012; 67:783-4.

Cagatay AA, Oncü SS et al Rhino-; cerebralmucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: A case report. BMC Infect Dis. 2001:222001.

Ericsson M, Anniko M et al. A case of chronic progressive rhino-cerebral mucormycosis treated with liposomal amphotericin B and surgery. Clinical Infecticous Disease. 2002 585–586.

Rasoul Mohammadi,Mohsen Meidaniet al. Case series of rhino-cerebralmucormycosis occurring in diabetic patients.Caspian J Intern Med. 2015 Autumn; 6(4): 243–246.

Ya-Chun Hsiao, Kun-Wu Tsan et al. Rhinocerebral Mucormycosis in Diabetes:A Case Report. J Intern Med Taiwan 2002;13: 160-164 ) J Intern Med Taiwan 2002;13: 160-164.


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