“SOLID AS SOLVENT”- NOVEL SPECTROPHOTOMETRIC DETERMINATION OF PIROXICAM IN SOLID DOSAGE FORM USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND PARACETAMOL) AS SOLUBILIZING AGENTS (MIXED SOLVENCY CONCEPT)

Mulani. P, Padiyar. A, Maheshwari R.K

Abstract


In proposed research, novel method for spectrophotometric estimation of piroxicam in tablet dosage form was
developed and validated as per ICH guidelines. The main objective behind research is to explore applications of
mixed solvency concept in analysis of various poorly soluble drugs. Generally in spectrophotometric analysis of poorly water soluble drugs,
class II and III organic solvents are used which are very toxic to humans as well as nature. The present study deals with novel
spectrophotometric estimation of piroxicam in solid dosage form using eutectic liquid of phenol and paracetamolin 4:1 ratio (PPl41) as
solubilising agents. As per the statement of Maheshwari, each substance (gas, liquid or solid) possessessolubilising power. PPl41possesses
signi􀃶cant large solubilizing power for piroxicamand having solubility more than 110 mg per ml whereas aqueous solubility of piroxicam is
0.4 mg/ml. Calibration curve of piroxicam was plotted by recording the absorbance of standard solutions (5,10,15,20 and 25μg/ml) of
piroxicam which were made by diluting the stock solution of piroxicam(50 mg) in PPl41 (10ml) with distilled water. The absorbances were
recorded at 358 nm against respective reagent blanks.The percent label claims were found very close to 100 (98.66 ± 1.761 and 99.33 ±
0.904) indicating accuracy of the proposed method. The accuracy and reproducibility of the proposed method was further con􀃶rmed by
recovery studies. Percent recoveries estimated by the proposed method are close to 100 (99.86 ± 1.878 to 101.65 ± 1.444). The low values of
standard deviation, percent coefficient of variation and standard error, validate the method.Thus, it may be concluded that proposed
method is simple, safe and precise and exclude use of toxic organic solvents. Phenol does not interfere above 300 nm and paracetamol does
not interfere above 315 nm in spectrophotometric analysis.


Keywords


Mixed Solvency, Spectrophotometric Analysis, Eutectic Liquid, Phenol, Paracetamol

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References


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