Handoko Halim, Ratna Akbari Ganie, Gontar Alamsyah Siregar


Liver cirrhosis is the third largest cause of death after cardiovascular and cancer. HCC is a liver malignancy that
requires early diagnosis. Biological effects of vitamin D include the effects of anti-proliferation, anti-angiogenesis,
pro-differentiation, anti-in􀃸ammatory, pro-apoptosis, and immunity regulation. Previous studies reported that chronic liver patients had
low levels of 25-hydroxyvitamin D. The aim of this study is to differ 25-hydroxyvitamin D serum level between liver cirrhosis and
hepatocellular carcinoma patients. Cross-sectional study of 32 consecutive admitted patients in Haji Adam Malik General Hospital Medan
from December 2017 to March 2018. Patients were classi􀃶ed as liver cirrhosis and hepatocellular carcinoma patients. Full blood count,
hemostasis and liver function test were done. AFP and 25-hydroxyvitamin were measured. Univariate analysis and bivariate were done with
SPSS version 24. There was no signi􀃶cant difference between 25-hydroxyvitamin D serum level on liver cirrhosis and hepatocellular
carcinoma patients (p = 0.052).


liver cirrhosis, hepatocellular carcinoma, AFP, 25-hydroxyvitamin D

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