PERIODONTAL PERSPECTIVES OF AUTOLOGOUS BLOOD PREPARATIONS

Pavankumar Addanki, Mounika Basvaraju

Abstract


Periodontitis is an infectious disease of attachment apparatus. Untreated periodontitis leads to bone loss and attachment loss. Though several periodontal treatments are available, only some of them are regarded as truly regeneration. Regeneration is reconstitution of both hard and soft tissues in structure and function. Various modalities i.e. bone grafts and substitutes, guided tissue regeneration (GTR) membranes and polypeptide growth factors (PGFs) are used for periodontal regeneration. Platelet concentrates are richest source for polypeptide growth factors. This review highlights various platelet concentrates, and there clinical applications in the treatment of periodontal diseases.


Keywords


Periodontitis, Growth factors, Platelet rich plasma, Fibrin tissue adhesive

Full Text:

PDF

References


Polimeni G, Xiropaidis AV, Wikesjo UM. Biology and principles of periodontal wound healing/regeneration. Periodontol 2000 2006; 41:30-47.

Pradeep AR, Shetty SK, Garg G, Pai S. Clinical effectiveness of autologous platelet-rich plasma and peptide-enhanced bone graft in the treatment of intrabony defects. J Periodontol 2009; 80:62-71.

Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, and Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1998; 85:638-646.

Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg 2004; 62:489-496.

Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H et al. Platelet-rich plasma contains high levels of platelet derived growth factor and transforming growth factor- and modulates the proliferation of periodontally related cells in vitro .J Periodontol 2003;74:849-857.

Arora NS, Ramanayke T, Ren YF, Romano GF. Platelet-rich plasma: a literature review. Implant Dent 2009; 18(4):303–308.

Dori F, Nikolidakis D, Huszar T, Arweller NB, Gera I, Sculean A. Effect of platelet-rich plasma on the healing of intrabony defects treated with natural bone mineral and a collagen membrane. J Clin Periodontol 2007; 34: 254-261.

Piemontese M, Aspriello SD and Rubini C, Ferrante L, Procaccini M.Treatment of periodontal intrabony defects with de mineralized freeze-dried bone allograft in combination with platelet-rich plasma: A comparative clinical trial. J Periodontol 2008; 79:802-810.

Camargo PM, Lekovic V, and Weinlaender, Divnic-Resnik T, Pavlovic M, Kenny EB. A surgical re entry study on the influence of platelet-rich plasma in enhancing the regenerative effects of bovine porous mineral and guided tissue regeneration in the treatment of intrabony defects in humans.J Periodontol 2009;80:915-923.

Haranack L, Boedeker RH, Kurtulus I, Boehm S, Gonzales J, Meyle J et al. Use of platelet-rich plasma in periodontal surgery –A prospective randomized double blind clinical trial. Clin Oral Investig 2009; 13:179-183.

Kaushick BT, Jayakumar ND ,Padmalatha O, Varghese S. Treatment of human periodontal infrabony defects with hydroxyapatite + β tricalcium phosphate bone graft alone and in combination with platelet rich plasma: a randomized clinical trial. Indian J Dent Res. 2011; 22(4):505-10.

Ozdemir B, Okte E. Treatment of intrabony defects with beta-tri calcium phosphate alone and in combination with platelet-rich plasma. J Biomed Mater Res B Appl Biomater. 2012; 100(4):976-83.

Pradeep A.R, Rao N S ,Agarwal E, Bajaj P,Kumari M, Naik SB .Comparative evaluation of autologous platelet-rich fibrin and platelet –rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis randomized controlled clinical trial.J Periodontol 2012;83:1449-1457.

Menzes LM, Rao J. Long term clinical evaluation of platelet-rich plasma in the treatment of human periodontal intraosseous defects: A comparative clinical trial. Quintessence Int 2012; 43:571-582.

.HassanKS, Alagl AS , Abdel-Hady A. Torus mandibularis bone chips combined with platelet rich plasma gel for treatment of intrabony osseous defects: clinical and radiographic evaluation. Int J Oral Maxillofac Surg. 2012; 41(12):1519-26

Kukreja BJ, Dodwad V ,Kukreja P , Ahuja S, Mehra P. A comparative evaluation of platelet-rich plasma in combination with demineralized freeze-dried bone allograft and DFDBA alone in the treatment of periodontal intrabony defects: A clinic radiographic study.J Indian soc periodontal 2014; 18(5):618-623.

Agarwal A, Gupta ND. Platelet-rich plasma combined with decalcified freeze-dried bone allograft for the treatment of non contained human intrabony periodontal defects: a randomized controlled split-mouth study. Int J Periodontics Restorative Dent. 2014; 34(5):705-11.

Pinipe J, Mandalapu NB and Manchala SR ,Mannem S, Gottumukkala S, Koneru S .Comparative evaluation of clinical efficacy of β-tri calcium phosphate (Septodont-RTR) alone and in combination with platelet rich plasma for treatment of intrabony defects in chronic periodontitis. J Indian Soc Periodontol. 2014; 18(3):346-51.

Keceli HG, Sengun D ,Berberoglu A ,Karabulut E. Use of platelet gel with connective tissue grafts for root coverage: A randomized-controlled trial. J Clin Periodontol 2008; 35:255-262.

Lafzi A, Chitsazi MT and Farahani RM ,Faramarzi M .Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession. Am J Dent. 2011; 24 (3):143-7.

.Jovovic B, Lazic Z and Nedic M , Matijevic S, Gostovic-Spadijer A. Therapeutic efficacy of connective tissue auto transplants with periosteum and platelet rich plasma in the management of gingival recession. Vojnosanit Pregl. 2013; 70(7):664-9.

Aimetti M, Romano F, and Deliava C et al.Sinus grafting using autogenous bone and platelet-rich plasma: Histological outcomes in humans. Int J Periodontics Restorative Dent 2008; 28: 585-591.

Schaff H, Streckbien P, and Lendeckel S, Heidinger K S, Rehmann P, Bodeker RH et al.Sinus lift augmentation using autogenous bone grafts and platelet-rich plasma. Radiographic results. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106:673-678.

Torres J, Tamimi F, Martinez PP, Alkhraisat MH, Linares R, Hernandez G et al. Effect of platelet-rich plasma on Sinus lifting: A randomized clinical trial. J Clin Periodontol 2009; 36: 677-687.

Khairy NM, Shendy EE, Askar NA , El-Rouby DH. Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial). Int J Oral Maxillofac Surg. 2013; 42(2):249-55.

Sunitha Raja V, Munirathnam Naidu E. Platelet rich fibrin: evolution of a second generation platelet concentrate. Indian J Dent Res 2008; 19:42–46.

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al .Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: e37–e44.

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:e51–e55.

Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:e56–e60.

Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol 2011; 38 (10):925-32.

Rosamma Joseph V, Raghunath A ,Sharma N. Clinical effectiveness of autologous platelet rich fibrin in the management of infrabony periodontal defects. Singapore Dent J 2012; 33(1):5-12.

Bansal C, Bharti V. Evaluation of efficacy of autologous platelet-rich fibrin with demineralized-freeze dried bone allograft in the treatment of periodontal intrabony defects. J Indian Soc Periodontol. 2013; 17(3):361-6.

Mathur A, Bains VK, and Gupta V ,Jhingran R, Singh G.P. Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis. Eur J Dent. 2015; 9(1):100-8.

Shah M, Patel J, and Dave D , Shah S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J Indian Soc Periodontol. 2015; 19(1):56-60.

Ajwani H, Shetty S, Gopalakrishnan D. Comparative evaluation of platelet-rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. Int Oral Health. 2015; 7(4):32-7.

Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trial. Acta Odontol Scand. 2015; 14:1-8.

Pradeep A.R. , Nagpal K, Karvekar S , Patanaik K, Naik SB, Guru Prasad CN. Platelet rich fibrin with 1%Metformin for the treatment of intrabony defects in chronic periodontitis: A randomized clinical trial. J Periodontol 2015; 86(6):729-737.

Gupta SJ, Jhingran R, Gupta V , Bains VK, Madan R, Rizvi I. Efficacy of platelet-rich fibrin vs. enamel matrix derivative in the treatment of periodontal intrabony defects: a clinical and cone beam computed tomography study. J Int Acad Periodontol. 2014; 16(3):86-96.

Del Corso M, Sammartino G, Dohan Ehrenfest DM. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study". J Periodontol. 2009; 80(11):1694-7

.Sofia Aroca, Tibor Keglevich , Bruno Barbieri et al. Clinical evaluation of modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study. J Periodontol 2009;80(2):244-252.

Jankovic S, Aleksic Z, Klokkvold P ,Lekovic V, Dimitrijevic B, Kenny EB, Camargo P.Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial. Int J Periodontics Restorative Dent 2012; 32:e41-e50.

Padma R, Shilpa A , Kumar PA ,Naga sri M, Kumar C, Sreedhar A. A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller's class-I and II recession defects. J Indian Soc Periodontol. 2013; 17(5):631-637

Eren G, Atilla G. Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig. 2014; 18(8):1941-8.

Tunali M, Ozdemir H , Arabaci T , Gurbuzer B, Pikdoken L, Firatli E. Clinical evaluation of autologous platelet-rich fibrin in the treatment of multiple adjacent gingival recession defects: a 12-month study. Int J Periodontics Restorative Dent. 2015; 35(1):105-14

Thamaraiselvin, Elavarasu S , Thangakumaran S ,Gadgi JS, Arthie T. Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession. J Indian Soc Periodontol. 2015; 19(1):66-71.

Toffler M, Toscano N , Holtzclaw D .Osteotome-mediated sinus floor elevation using only platelet-rich fibrin: an early report on 110 patients. Implant Dent. 2010; 19(5):447-56.

Zhang Y, Tangl S , Huber CD ,Lin Y, Qiu L, Rausch-Fan X. Effect of Choukroun’s platelet rich fibrin on bone regeneration in combination with deprotienzed bovine bone material in maxillary sinus augmentation: A histological and histomorphometric study. J Crainomaxillofac Surg 2012; 40(4):321-8.

Sharma A, Pradeep A.R.. Autologous Platelet-rich fibrin in the treatment of mandibular degree II furcation defects: A randomized clinical trial. J Periodontol 2011; 82:1396-1403.

Bajaj P, Pradeep AR and Agarwal E , Rao NS, Naik SB , Priyanka N et al. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. J Periodontal Res. 2013; 48(5):573-81.

Hauser F, Gaydarov Nand Badoud I et al. Clinical and histological evaluation of post extraction platelet-rich fibrin socket filling: a prospective randomized controlled study. Implant Dent. 2013; 22(3):295-303.

.Barone A, Ricci M and Romanos GE et al. Buccal bone deficiency in fresh extraction sockets: a prospective single cohort study. Clin Oral Implants Res. 2014; 31:45-49

Hamzacebi.B, Oduncuoglu B , Alaaddinoglu EE. Treatment of Peri-implant Bone Defects with Platelet-Rich Fibrin. Int J Periodontics Restorative Dent. 2015; 35(3):415-22.

M. Tunali, H. Ozdemir, Z. Kuçukodaci, S. Akman, E. Yaprak, E. Firatli et al. “In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate” .Br J Oral Maxillofac Surg 2012; 51(5): 438–443.

.S. Takemoto, T. Yamamoto, K. Tsuru, S. Hayakawa, A. Osaka, S. Takashima et al. “Platelet adhesion on titanium oxide gels: effect of surface oxidation”. Biomaterials 2004; 25(17); 3485–3492.


Refbacks

  • There are currently no refbacks.