OXIDATIVE STRESS IN DIABETES MELLITUS PATIENTS : A STUDY OF MALONDIALDEHYDE (MDA) AND ISCHEMIA MODIFIED ALBUMIN (IMA) AS INDICATORS OF OXIDATIVE STRESS.

Neerja Agrawal, Swati Hiwale

Abstract


Background:Hyperglycaemia in diabetic condition is metabolic dysfunction which can lead to increased free radical production causing oxidative damage and stress. The present study aims to evaluate malondialdehyde (MDA), ischemia modified albumin (IMA) concentrations in diabetics, as a marker of oxidative stress. Methodology: A total of 60 diabetic subjects with 45 age, sex matched healthy controls. MDA and IMA were assessed from serum using standardised method and were compared amongst diabetic subjects and control subjects. Results: Two groups were found to be matched for general characteristics. The concentration of MDA and IMA was found to be increased significantly in diabetics compared to normal controls. Further MDA and IMA were also found to be significantly higher in male diabetic subjects compared to female diabetic subjects when differences in non diabetic male and female subjects failed to reach statistical significance. Conclusion: Diabetic subjects show high levels of MDA and IMA those can be result of oxidative stress of the hyperglycaemic state.


Keywords


diabetes mellitus, malondialdehyde (MDA), ischemia modi

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