Relation of depression with C reactive protein

Dr Ramghulam Razdan, Dr Pali Rastogi, Dr Gaurav Chittora, Dr Prafulla Songara


Objective- To study the clinical profile of studied sample. To study the severity, duration, age of onset of depression and its
relation to inflammatory mediator in depression.
Materials and Methods- 100 Newly diagnosed patients of Depression as per ICD 10 (International classification of diseases)
DCR(Diagnostic criteria for research) were selected for study after applying strict inclusion and exclusion criteria. Severity of depression was
measured by HRSD scale. Blood sample of participants was obtained and CRP was assessed.
Results- In our study 52% patients had age of onset of depression between 18-29 years, 22% patients had recurrent depression, 76% patients
had duration of current episode of <1 year, and in 20% patients, family history of psychiatric illness was present. Mean of baseline CRP was
higher in 41-50 years age group compared to younger age groups but it was not significant. Mean of baseline CRP was higher in females but it
was not significant. Mean of baseline CRP was higher in recurrent depressive patients but it was not significant. Mean of Baseline CRP was
higher in patients those who have duration of current episode >1 year but it was not significant. Mean of Baseline CRP was slightly higher in
patients those who do not have family history of psychiatric illness and it was found not significant.
Conclusion- ese findings suggest that CRP is correlated with depression


Hamilton rating scale for depression, c reactive protein, depression

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