“RARE CASE OF NON IMMUNE HYDROPS FOETALIS IN A HEPATITIS B POSITIVE MOTHER”

Dr. Sagarika Babu, Dr. Lakshmi Manjeera M

Abstract


INTRODUCTION: 85% of hydrops fetalis cases are non immune due to widespread immunoprophylaxis for red cell
alloimmunization. NIHF incidence being 1:2500-3500. 4-15% cases contribute to infectious causes. Hepatitis B infection
being the rarest of all. CASE REPORT: 30yr old G2 A1, conceived following 4th cycle of IUI(donor) was referred to us at 28weeks+4days of
gestational age with NIHF and polyhydramnios. She was diagnosed, hepatitis B positive prior to conception. Repeat scan done:-
polyhydramnios(25.8cms), UAD - AEDV, uterine artery PI – 1.26, gross cardiomegaly, absent stomach bubble and fetal ascites. Due to poor
prognosis of the fetus and as she developed “Mirror syndrome” pregnancy was terminated. She delivered a dead edematous male fetus. Skin
karyotyping and chromosomal study:-normal. Autopsy:- no significant finding. CONCLUSION: It can be assumed that Hepatitis B infection as
cause of fetal hydrops may be underdiagnosed.


Keywords


Non-immune hydrops fetalis, Mirror syndrome, Hepatitis B infection

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References


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Ghendon Y, Perinatal transmission of hepatitis B virus in high-incidence countries. J Virol Methods 17(1-2):69-79


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