Ashish Gajera, Sunil kumar Shah, C. K Tyagi, Shridhar Pandya, Naitik Trivedi


Olmesartan medoxomil (OLM) is a novel selective angiotensin II receptor blocker USFDA approved drug for the
treatment of hypertension. The oral bioavailability of OLM is 26% in healthy humans due to low solubility in water. The
aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the solubility of OLM. The
screening study of OLM with different oils, surfactants and co-surfactants was done. Out of study optimized batch was converted in to solid freeze
dried powder using 2% w/v mannitol as cryoprotcatant by lyophilization technique. This freeze dried powder shown good ow properties. The in
vitro dissolution shown that about 99.28±0.013% of the drug is released within 45 min in freeze dried Solid-SMEDDS, while plain drug showed
only 37.88±0.025% and marketed tablet shown only 58.31±0.015 % dissolution at the end of 45 min. The in vitro dissolution studies indicate that
formulation of OLM in the form of freeze dried powder enhances the dissolution properties.


Olmesartan medoxomil, solid self-microemulsifying drug delivery system, enhance solubility

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