SERUM URIC ACID LEVELS IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH MICROALBUMINURIA

Dr. Muthineni Pavan Kumar, Dr. Nishanam Gururaj, Dr. Payal Gaggar

Abstract


Raised serum uric acid has been reported to be associated with an increased risk of coronary Heart disease and is
commonly encountered with essential hypertension, even untreated Hypertension, and type 2 diabetes, which are in turn
associated with coronary heart disease. Increased serum uric acid level combined with hypertension might cause an endothelial dysfunction and
result in glomerular hypertension, which would induce microalbuminuria and hyper ltration.
AIM : This study was done to determine whether raised serum uric acid levels was an independent risk factor for developing hypertension.
OBJECTIVES:
(1) T o study the relationship between serum uric acid levels and hypertension.
(2)To study the relationship between serum uric acid levels and severity of hypertension.
(3)To study the relationship between serum uric acid levels and microalbuminuria (marker of target organ damage) in hypertensives.
STUDY DESIGN: Prospective observational study
MATERIAL AND METHODS: 200 patients who attended in-patient or out-patient clinic in the department of Medicine, MGM hospital,
Warangal during the period of one year were evaluated for Serum Uric Acid levels and urinary Microalbumin levels of which 100 were cases and
100 were controls.
INCLUSION CRITERIA:-
1) Known cases of essential hypertension; according to JNC VIII classication.
2) Male and Female patients >18 years and < 65 years of age.
EXCLUSION CRITERIA:-
Ÿ Diabetes Mellitus,
Ÿ Ischemic Heart Disease,
Ÿ All cases of secondary hypertension,
Ÿ Clinical ndings of Gout or extraarticular manifestations of hyperuricemia
Ÿ Obesity ( BMI > 25 )
Ÿ H/o alcohol abuse
Ÿ H/o drugs known to cause hyperuricemia, e.g. thiazide diuretics, anticancer therapy.
Ÿ History of leukemia, polycythemia, lymphoma or any neoplastic disease.
Ÿ H/o Renal disease, Patients with UTI
Ÿ H/o pre-eclampsic toxemia
RESULTS: In the present study patients are in the age group of 31-65 years with mean age of 51.7 years. Mean serum uric acid in stage 1
hypertensives was 6.21±2.05 and in stage 2 hypertensives were 4.79±1.85. The serum uric acid was signicantly higher in all stages of
Hypertension when compared to the normotensives, but hyperuricemia did not correlate with the severity of hypertension.
CONCLUSION: Serum uric acid is higher in hypertensives and did not correlate with the severity of hypertension. Serum uric acid is higher in
hypertensives with microalbuminuria and hence a surrogate marker for target organ damage.


Keywords


hypertensives microalbuminuria Microalbumin

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References


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