Tripti Nagdev, Smita Joshi


Introduction: Laryngoscopy and Endotracheal Intubation is the gold standard for airway management.We used iv
dexmedetomidine 1μg/kg and iv fentanyl 2μg/kg. Aim:To compare attenuation of pressor response and compare the
effect of maintaining the haemodynamic stability during laryngoscopy and endotracheal intubation.
Methods and Materials : 15 to 65 years of ASA grade I and II posted for surgery.Patients were selected randomly and allocated into Group D: (n-
30) received 1ug/kg of dexmedetomidine iv slowly after recording baseline vitals , diluted with normal saline to make 10ml Group F: (n-30)
received 2ug/kg fentanyl iv slowly diluted with normal saline to make 10ml.
Results : The demographic data was comparable, we found that iv Dexmedetomidine in the dose of 1 μg/kg and iv Fentanyl 2μg/kg given ten
minutes prior to induction , both attenuated the hemodynamic responses to laryngoscopy and endotracheal intubation. The attenuation of heart
rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure was better in group D.
Conclusion : Intravenous Dexmedetomidine 1 μg/kg given 10 minutes prior to surgery was superior to intravenous Fentanyl 2μg/kg .


Dexmedetomidine , Fentanyl , Laryngoscopy.

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