Dr Katta Subraya Prakash Rao, Dr Karthikeya T M


Background : Dengue is an acute viral illness with sometimes fatal complications. To reduce the associated mortality
and morbidty, early diagnosis and prompt management becomes essential. This study was undertaken to evaluate the
commonly employed laboratory parameters and also to highlight the importance of the less commonly used investigations which might be of
Methods: A cross sectional study was conducted among 200 patients suspected to have dengue infection. Clinical examination and relevant
blood investigations were done.
Results: Out of 200 patients , 52 (26%) were found positive for dengue. 25.5% were positive for NS1 antigen only. Leukopenia and
thrombocytopenia were seen in cases with dengue. Ferritin and liver enzymes were found to be elevated.
Conclusion: Dengue is endemic in India. No specic treatment is currently available for this disease. Early diagnosis, proper care and
management can only reduce the mortality associated with this disease.


Dengue, Thrombocytopenia, Hyperferritinemia.

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Vicente C R, Herbinger K H, Froschl G, Romano C M, Cabidelle A, Cerutti Junior C. Serotype influences on dengue severity: A cross sectional study on 485 confirmed dengue cases in Vitoria , Brazil. BMC Infect Dis 2016; 16:320.

Dengue. Dengue Fact sheet. Neglected tropical diseases. World Health Organization. Available at http://www.searo.who.int/entity/vector_borne_tropical_diseases/data/data_factsheet/en/

WHO fact sheet. Vector Borne diseases. World Health Organization. Available at http://www.who.int/kobe_centre/mediacentre/vbdfactsheet.pdf

Goel A, Patel D N, Lakhani KK, Agarwal S B, Agarwal A, Singla S et al. Dengue fever – A Dangerous Foe. Journal, Indian Academy of Clin Med 2004; 5(3):247-58.

Khayyam N, Agarwal M, Dalela G, Chundawat B, Panda J, Sharma V. Antibody detection of dengue infection in clinically symptomatic patients by MAC-ELISA during post monsoon season at a tertiary care hospital at Jaipur, Rajasthan. Int J Med Sci Ed 2017;4(3):252-256.

Srikiatkhachom A. Plasma leakage in dengue hemorrhagic fever. Thrombhaemost 2009; 102(6):1042-1049.

World Health Organization. The World health report 1996: fighting disease, fostering developing. Geneva: World Health Organization; 1997

The Hindu. India leads the world in dengue burden (cited September 12, 2013). Available at URL: http://www.thehindu.com/scitech/health/policy-and-issues/india-leads-the-world-in-dengueburden-nature/article4592098.ece 08April 2013.

Gubler DJ, Clark GG. Dengue/dengue hemorrhagic fever the emergence for a global health problem. Emerg Infect Dis. 1995:1:55- 57. 15.

World Health Organization. Dengue hemorrhagic fever: Diagnosis, Treatment, Prevention and Control. 2nd ed. Geneva: World Health Organization; 1997

Neeraja M, Lakshmi V, Teja VD, Umabala P and SubbalakshmiMV.Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital. Indian J Med Microbiol 2006; 24: 280-2.

Dash PK, Saxena P, Abhavankar A, Bhargava R and Jana AM. Emergence of dengue virus type 3 in Northern India. Southeast Asian J Trop Med Public Health 2005; 36: 370-77.

Mehta T K, Shah P D. Evaluation of recent WHO Classification (2009) for assessment of Dengue Disease Severity.Int J CurrMicrobiol App Sci 2015; 4(9):755-765.

Mehta SR, Bafna TA, Pokale AB. Demographic and Clinical spectrum of Dengue patients admitted in a Tertiary care hospital. Med J DY PatilVidyapeeth 2018;11:128-131.

Deshwal R, Qureshi MI, Singh R. Clinical and laboratory profile of dengue fever. J Assoc Physicians India 2015;63:30 2.

Kanthikar SN, Kalshetti VT. Correlation of thrombocytopenia and serological markers in early diagnosis of dengue infection with special reference to NS1 antigen. Ind J PatholOncol 2016; 3(3):437-439.

Lale A, Lale S, Bick R, Fareed J. Dengue fever and thrombocytopenia: A deadly Duo. Blood 2006;108:3978.

Khan DM, Kuppusamy K, Sumathi S, Mrinalini V R. Evaluation of thrombocytopenia in dengue infection along with seasonal variation in Rural Melmaruvathur. J ClinDiagn Res 2014;8(1):39-42.

De Castro RA, de Castro JA, Barez MY, Frias MV, Dixit J, Genereux M. Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh (o) -D) immune globulin. Am J Trop Med Hyg. 2007;76(4):737–42

Patel PM, Patel SK, Sabalpara MA, Shah CK, Shah NR. Study of hematological and biochemical changes in dengue fever at tertiary care hospital at Ahmedabad. Inter J Medic Sci Pub Heal. 2016;5(9):1934-6

Meena KC, Jelia S, Meena S, Arif M, Ajmera D, Jatav VS. A study of hematological profile in dengue fever at tertiary care center, Kota Rajasthan, India. Inter J Adv in Medic. 2016;3(3):621-4.

Khatri K, Rajani A, Khalla AR. Plasmacytoid lymphocytes: a diagnostic clue to dengue infection. Int J Sci Res. 2016;5(3):1002-5.

Ch. Manoj Kumar, K. S. Keerthi Vyas, Y. Sai Krishna. Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India. Inter J Res Medic Sci. 2017;5(5):1751- 1755

van de Weg CAM, Huits RMHG, Pannuti CS, Brouns RM, van den Berg RWA, et al. (2014) Hyperferritinaemia in Dengue Virus Infected Patients Is Associated with Immune Activation and Coagulation Disturbances. PLoSNegl Trop Dis 8(10): e3214

Daniel R, Rajamohan, Philip AZ. A study of clinical profile of dengue fever in Kollam,Kerala, India. Dengue Bulletin 29;2005:197-202.

Sharma S and Sharma SK. Clinical profile of DHF in adults during 1996 outbreak in Delhi, India. Dengue Bulletin. 1998; 22: 20-27.


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