Dr. Sagar Rakesh Tyagi, Dr. Shikha Goyal


This study was designed to compare effect of dexmedetomidine and fentanyl on cardiovascular responses during
intubation under general anesthesia. Sixty adult patients were randomly recruited to 2 groups of 30 each. Group
D:Dexmedetomidine group (0.5mcg/kg diluted to 10ml NS). Group F:Fentanyl group (2mcg/kg diluted to 10ml NS). Heart rate, systolic &
diastolic blood pressure were recorded prior to drug ,1 min after drug administration, at 30 sec, 1, 2, 3, 5, 7 & 10 minutes after intubation. Side
effects like bradycardia, hypotension, nausea, shievering & desaturation also noted. Heart rate was lower in group D at all time intervals. Systolic
and diastolic BP was lower in group D from 30 sec after intubation till end of study (p≤0.05). Bradycardia was found in 2 patient in group D. We
concluded that dexmedetomidine is more efcacious than fentanyl in attenuation of stress response during intubation period.


Stress Response, Intubation, Fentanyl, Dexmedetomidine

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Reid LC, Brace DE. Irritation of respiratory tract and its reflex effect on heart surgery. Gynaecology Obstetrics 1940;70:157-160.

Prys-Roberts C, Green LT, Meloche R, et al. Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation. Br J Anaesth 1971;43(6):531-547.

Dalton B, Guiney T. Myocardial ischemia from tachycardia and hypertension in coronary artery disease-patients undergoing anaesthesia. Boston: Ann Mtg American Society of Anaesthesiologists 1972:201-202.

Preys Roberts C. Anaesthesia and hypertension. British Journal of Anaesthesia 1984;56:711-724.

King BD, Harris LC, Greifenstein FE, et al. Reflex circulatory responses to direct laryngoscopy and tracheal intubation performed during general anaesthesia. Anaesthesiology 1951;12(5):556-566.

Stoelting RK. Blood pressure and heart rate changes during short-duration laryngoscopy for tracheal intubation: influence of viscous or intravenous lignocaine. Anesth Analg 1978;57(2):197-199.

Stoelting RK. Circulatory changes during laryngoscopy and tracheal intubation: influence of duration of laryngoscopy with or without prior lignocaine. Anaesthesiology 1977;47(4):381-384.

Martin DE, Rosenberg H, Aukburg SJ, et al. Low-dose fentanyl blunts circulatory response to tracheal intubation. Anaesth Analga 1982;61(8):690-694.

Stoelting RK. Attenuation of blood pressure response to laryngoscopy and endotracheal intubation with sodium nitroprusside. Anaesthesia Analgesia 1979;58(2):116-119.

Kharwar RK, Kumar M, Tiwary PK, et al. A comparison of intravenous dexmedetomidine vs. inj. fentanyl for attenuation of hemodynamic responses during laryngoscopy and intubation after propofol induction. NJIRM 2014;5(3):71-75.

Gandhi S, Goyal V, Radhakrishnan K, et al. Comparison of dexmedetomidine with fentanyl in attenuation of pressor response during laryngoscopy and intubation. IOSR Journal of Pharmacy 2014;4(2):28-38.

Das B, Palaria U, Sinha AK, Kumar S, Pandey S. A ComparativeStudy of Fentanyl and Dexmedetomidine in AttenuatingHaemodynamic Response of Laryngoscopy and Intubation. Ann. ofInt. Med. & Den. Res. 2015;1(1):9-12

Patel ND, Patel JJ, Patel DD, et al. A study on comparison of intravenous dexmedetomidine with intravenous fentanyl for suppression of hemodynamic responses to laryngoscopy and endotracheal intubation during general anaesthesia. Nat J Med Res 2015;5(2):127-131.

Jain V, Chandak A, Ghosh A, et al. Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation. Ains Shams Journal of Anaesthesiology 2015;8(2):236-243.

Jaakola ML, Ali-Melkkila T, Kanto J, et al. Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. Br J Anaesthesia 1992;68(6):570-575.

Lawrence CJ, De Lange S. Effects of single preoperative dexmedetomidine dose on isoflurane requirements and perioperative haemodynamic stability. Anaesthesia 1997;52(8):736-744.

Patel CR, Engineer SR, Shah BJ, et al. Effect of intravenous infusion of dexmedetomidine on perioperative haemodynamic changes and postoperative recovery: a study with entropy analysis. Indian J Anaesthesia 2012;56(12):542-546.


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