A COMPARATIVE CLINICAL STUDY OF DEXMEDETOMIDINE AND FENTANYL IN ATTENUATING STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Dr. Sagar Rakesh Tyagi, Dr. Shikha Goyal

Abstract


This study was designed to compare effect of dexmedetomidine and fentanyl on cardiovascular responses during
intubation under general anesthesia. Sixty adult patients were randomly recruited to 2 groups of 30 each. Group
D:Dexmedetomidine group (0.5mcg/kg diluted to 10ml NS). Group F:Fentanyl group (2mcg/kg diluted to 10ml NS). Heart rate, systolic &
diastolic blood pressure were recorded prior to drug ,1 min after drug administration, at 30 sec, 1, 2, 3, 5, 7 & 10 minutes after intubation. Side
effects like bradycardia, hypotension, nausea, shievering & desaturation also noted. Heart rate was lower in group D at all time intervals. Systolic
and diastolic BP was lower in group D from 30 sec after intubation till end of study (p≤0.05). Bradycardia was found in 2 patient in group D. We
concluded that dexmedetomidine is more efcacious than fentanyl in attenuation of stress response during intubation period.


Keywords


Stress Response, Intubation, Fentanyl, Dexmedetomidine

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References


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