EVALUATION OF TG/HDL CHOLESTEROL RATIO AND NON HDL/HDL RATIO AS A MARKER OF CARDIOVASCULAR RISK IN DIABETICS MELLITUS

Sunita D. Singh, Nita Garg

Abstract


Aim: The aim of our study was to determine lipid prole levels in diabetics and nondiabetics and to evaluate
cardiovascular risk using TG/HDLc ratio and Non HDLc/HDLc ratios.
Study Design: A hospital based cross sectional study was conducted on patients attending the Out Patient Department of Medicine of Doon
Medical College, Dehradun (Uttarakhand) during a period of 06 months from January 2018 to June 2018. 200 patients (100 Diabetics + 100 Nondiabetics)
in the age group 30-80 years were selected randomly for the study. Of the 100 Diabetics (52 Male + 48 Female) and of the 100 Non
diabetics 56 were males and 44 were females. All the participants underwent biochemical analysis-FBS, PPBS, HbA1C and lipid prole (TC,
TG, HDL), LDL, VLDL and Non-HDL were calculated by computational methods. TG/HDLc ratio and Non HDLc/HDLc ratios were also
calculated to assess cardiovascular risk.
Methodology: Biochemical & statistical analysis was done on all the selected 200 subjects. TG/HDL ratio and Non-HDLc/HDLc ratios were
calculated.
Results: Total Cholesterol, TG, LDL & TG/HDLc ratio & Non-HDL/HDL ratio were found to be signicantly increased in diabetics when
compared with non diabetics. HDL levels were found to be & slightly less in diabetics as compared to Non diabetics.
Conclusion: We concluded that Non HDlc/HDLc ratio & TG/HDLc ratio can be used as early markers of cardiovascular risk.


Keywords


Diabetes Mellitus, Non HDLc, TG/HDLc ratio, Non-HDLc /HDlc ratio.

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References


Meigs JB. Epidemiology of the metabolic syndrome Am J manag Care 2002; 8(11 supply): S283-92; quiz S293-96.

Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-1607.

Syvanne M, Taskinen M-R. Lipids and Lipo-proteins as coronary risk factors in non-insulin dependent Diabetes mellitus Lancet 1997:350(S1): S20-3.

Stamler J. Vaccaro O, Neaton JD et al. Diabetes other risk factors, and 12 year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:434-44.

Fox CS, Coady S, Sorlic PD et al. Trends in cardiovascular complications of diabetics. J. Amer Med Assoc 2004;292:2495-499.

Laakso M. Cardiovascular disease in type-2 diabetes challenge for treatment and prevention. J. Intern Med 2001;249:225-35.

Garg A, Grundy SM Management of dyslipidemia in NIDDM. DiabetesCare 1990;13:153-69.

Huggett A.S. Nixon DA; use of glucose oxidase, peroxidase,&O-dianisidine in determination of blood & urinary glucose Lancet 1957;273:368-70 (pubmed).

Allain C.C., Poon L.S. ; Chan C.S. et al. enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470-75 (pubmed).

Burstein M; Scholnick H.R, Morfin R. Rapid method for isolation of lipoprotein from human serum by precipitation with polyanion. J lipid Res. 1970;11:583-95(pubmed).

Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produce Hydrogen peroxide. ClinChem. 1982;28:2077-80(pubmed).

FriedwaldWi, Levy R.I, Fredrickson D.S. Estimation of the concentration of LDL cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502(pubmed).

American Diabetes Association website: Complication of Diabetes mellitus in United States. Availabe at www. Diabetes.org/diabetes-statistics/complications/jsp.Accessed January 29,2011.

Wilson PW. Kannel WB. Anderson KM. Lipids, glucose intolerance and vascular diseases: the Framingham study. MonogrAtheroscler 1985;13:1-11.

Sert M,Morgul G, Tetiker BT. Diabetic dyslipidema is a well known issue, but what about lipoprotein a levels in Type 2 diabetics? Int ‘IJ Diabetes Metab 2010;18:81-7.

Regmi P, Gyawali P, Shrestha R, et al. Pattern of dyslipidemia in Type II Diabetic subjects in Eestern Nepal. JNAMLS 2009;10:11-13.

Pandeya A, Sharma M, Ragni P et al. Pattern of dyslipidemia and evaluation of non HDL-Cholesterol as a marker of risk factor for cardiovascular disease in type-2 diabetes Mellitus. Nepal Med Coll J 2012;14(4):278-282.

Executive summary of the third Report of the National Cholesterol Education Programme (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J Amer Med Assoc 2001:285:2486-97.

Stampfer MJ, Sacks FM, Salvini S, Willett WC et al. A perspective study of cholesterol, apolioprotiens, and the risk of myocardial infarction. N Engl J Med 1991;325:373-81.


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