A COMPARATIVE STUDY OF EFFICACY OF TOPICAL PHENYTOIN VERSUS CONVENTIONAL WOUND CARE IN DIABETIC ULCERS

Dr. A. Anusha, Dr. M. V. Reddy, Dr. P. Vijayendra

Abstract


INTRODUCTION: Diabetic ulcer is a signicant healthcare problem with its healing depending on many factors. Many
agents have been tried in wound healing and one such agent is phenytoin. The aim of this prospective comparative study
was to compare the efcacy of topical phenytoin with conventional wound dressings in the healing of diabetic ulcers.
PATIENTS AND METHODS: This prospective comparative study included fty patients, with 25 patients in each group. The patients were
compared in terms of number of days required for healing, rate of granulation tissue formation, effect on bacterial load and skin graft up take.
OBSERVATIONS AND RESULTS: Both the groups were comparable in terms of patient demographics. Rate of granulation tissue formation
was more rapid in phenytoin group with a mean of 85.21% as compared to conventional moist dressing group with a mean of 70.32%. Hospital
stay was signicantly reduced in phenytoin group with a mean of 30.04 days compared to conventional moist dressing group with a mean of
45.10 days. Percentage of graft uptake is more in phenytoin group with a mean of 91.78% compared to conventional moist dressing group with a
mean of 75.48%.
CONCLUSION: Rate of granulation tissue formation, overall graft uptake, patient compliance and overall hospital stay were better in the
topical phenytoin dressing group. Thus, topical phenytoin moist wound dressing can be considered as a superior option in the management of
diabetic ulcers.


Keywords


Diabetic ulcers, Topical phenytoin, Conventional moist dressings.

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References


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