Bhukye Veeranna, Shaikh Mahmood, M.A. Waheed, D. Santha Rao


Plasma Homocysteine (PHcy) and Blood Ammonia (BA) Levels are proposed to be involved in hepatic fibronogenesis
and portosystemic encephapathy. Plasma Homocysteine (PHcy) and Blood Ammonia (BA) levels are increased in post
absorptive patients with biopsy proven liver cirrhosis. There is also evaluating spenomegaly and hypersplnism (Thrombocytopenia) for the
severity of liver cirrhosis patients. Identifying cirrhosis patients with high levels of plasma Homocysteine (PHcy) and Blood Ammonia (BA)
concertration could be clinically useful.


Liver Cirrhosis, Plasma Homocysteine (PHcy) and Blood Ammonia (BA), Fibronogenesis, Portosystemic Encephapathy Spenomegaly And Hypersplnism Thrmbocytopenia

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Martí-Carvajal AJ, Solà I, Lathyris D, Salanti G. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev 2009; (4):

Kharbanda KK. Alcoholic liver disease and methionine metabolism. Semin Liver Dis 2009; 29(2): 155î65

Tarantino G, Gentile A, Capone D, Basile V, Tarantino M, Di Minno MN, CuocoloA, Conca P. Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression? World J Gastroenterol. 2007;13:4903–4908.

Alempijevic T, Bulat V, Djuranovic S, Kovacevic N, Jesic R, Tomic D, Krstic S, Krstic M. Right liver lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension. World J Gastroenterol. 2007;13:5331–5335.

Gerritzen-Bruning MJ, Ingh TS van den, Rothuizen J. Diagnostic value of fasting plasma ammonia and bile acid concentrations in the identification of portosystemic shunting in dogs. J Vet Intern Me. 2006;20:13–19. doi: 10.1892/0891-6640(2006)20[13:DVOFPA]2.0.CO;2.

Liu C, Ngai CY, Huang Y, Ko WH, Wu M, He GW, Garland CJ, Dora KA, Yao X. Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. Br J Pharmacol. 2006;147:506–515. doi: 10.1038/sj.bjp.0706639.

Riggio O, Efrati C, Catalano C, Pediconi F, Mecarelli O, Accornero N, Nicolao F, Angeloni S, Masini A, Ridola L, Attili AF, Merli M. High prevalence of spontaneous portal-systemic shunts in persistent hepatic encephalopathy: a case-control study. Hepatology. 2005;42:1158–1165. doi: 10.1002/hep.20905.

McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004; 350(20): 2042î9

Mirkoviý D, Majkiý-Singh N, Ignjatoviý S. Homocystine: chemistry, metabolism and role in pathophysiological processes. Jugoslov Med Biohem 2003; 22(2):127î40.CD006612.

Refsum H, Fiskerstrand T, Guttormsen AB, Ueland PM. Assessment of homocysteine status. J Inherit Metab Dis 1997; 20(2): 286î94.

Nicolao F, Efrati C, Masini A, Merli M, Attili AF, Riggio O. Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy. J Hepatol. 2003;38:441–446. doi: 10.1016/S0168-8278(02)00436-1.


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