“EFFECT OF AGE ON THYROID PROFILE IN CHRONIC KIDNEY DISEASE’’

Manpreet Saini, Gurpreet Kaur, Sona K. Gupta

Abstract


Aim: The aim of this study was to establish a correlation & nd effect of Age on Serum T3,T4, TSH values of Chronic
kidney disease patients.
Study Design: A hospital based Non-Experimental Observational Cross-sectional & Correlation Study was conducted on patients of both sex
attending the Out Patient Department & In Patient Department of Nephrology & Medicine of SMI Hospital, P.Nagar Dehradun for a period of 4
months from January 2014 to April 2014. Study comprises 54 Chronic kidney disease patients which were divided into ve age groups i-e Age
group- 15-29yrs, Age group- 30-44yrs, Age group-45-59yrs, Age group- 60-74yrs, Age group- ≥75yrs. Inclusion criteria was patients with
evidence of Chronic kidney disease selected randomly of both sex & age above 15 years. Exclusion criteria was age <15 years & those not
willing to participate.
Methdology: Consecutive sampling technique & Bio-physiological method of collection of Data was used .5ml blood was collected in sterile
tubes from the fasting (8-12hrs) Chronic kidney disease patients & was analyzed for Serum T3, T4, TSH values by enzymatic method using
VITROS ECIQ,an auto analyser at SMI Hospital, P.Nagar, Dehradun. Correlation coefcient i-e r-value & p-value was analysed using
Microsoft ofce Excel 2007 .Positive r- value represented positive correlation between that age group & that parameter & vice versa. P<0.05 was
considered signicant & P<0.01was considered highly signicant
Results: Age group 15-29yrs was found to have positive Correlation coefcient with S. T3, T4 & TSH values of Chronic kidney disease patients
& there was signicant(P<0.05) relationship of this age group with S. T3, T4,TSH values of Chronic kidney disease patients.
Age group 30-44yrs was found to have negative Correlation coefcient with S. T3, T4 & positive Correlation coefcient with S. TSH values of
Chronic kidney disease patients. Relationship of S.T3 & TSH was found to be Non signicant (P>0.05) & S.T4 was found to have Highly
signicant (P<0.01) relationship with this Age group.
Age group 45-59yrs was found to have negative Correlation coefcient with S. T4,TSH & positive Correlation coefcient with S.T3 values of
Chronic kidney disease patients. Relationship of S.T3,T4 & TSH was found to be Non signicant (P>0.05) with this Age group.
Age group 60-74yrs was found to have negative Correlation coefcient with S. T3 & positive Correlation coefcient with S. T4 & TSH values of
Chronic kidney disease patients. Relationship of S.T3,T4 & TSH was found to be Non signicant (P>0.05) with this Age group.
Age group ≥75yrs was found to have negative Correlation coefcient with S. T3,T4 & positive Correlation coefcient with S. TSH values of
Chronic kidney disease patients. Relationship of S.T3,T4 & TSH was found to be Non signicant (P>0.05) with this Age group.


Keywords


Chronic Kidney Disease, Age Group, Thyroid Prole.

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