R. Chacha, S. Afqir


Lung cancer is the first cause of death cancer in the worldwide. There is an important development of agents which aimed
the PD-1/PD-L1 axis and that d has a great influence on the strategy of the treatment of lung cancer in first and second line.
Pembrolizumab is approved by the U.S. FDA for the treatment of advanced NSCLC progressed after other therapies and with expression of PD-L1.
This review highlights the results of recent clinical trials on pembrolizumab for the treatment of non-small cell lung cancer.


immunotherapy, lung cancer, PD-1/PD-L1

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