A comparative analysis of tumor control and normal tissue complication probability in consequential Radiotherapy plans of Carcinoma cervix using 6 MV X-ray and Cobalt -60 gamma rays

Dr. Anoop Kumar Srivastava, Dr. Madhup Rastogi, Dr. S.P. Mishra


20 cases of carcinoma cervix were planned on treatment planning system and optimal plan was obtained with the help of dose volume histogram(DVH) which was further utilized for evaluating the plan radiobiologically. The tumor control probability (TCP) and normal tissue complication probability (NTCP) was calculated with the help of BIOPLAN for the total dosage planned includingbrachytherapy.NTCP for rectum and bladder was obtained using Lyman-Kutcher-Burman(LKB) and relative seriality model.  TCPwas evaluated both by BIOPLAN and Brenner’s formula. It was found thatGamma photon of Co-60 couldalso provide equivalent consequential plan   comparable to 6 MV x-rays. Since visual inspection of dose distribution in of DVH or on CT slices can only form the basis to select the optimal treatment plan, it is imperative for objective treatment plan evaluation to deduce the outcome in terms of radiobiological parameters.



Full Text:



Prescription, Recording and Reporting Photon Beam Therapy, ICRU Report 50, ICRU, Bethesda, Maryland USA, 1993

Prescription, recording and Reporting Photon Beam Therapy (supplement to ICRU Report 50), ICRU Report 62, 1999

Prescribing, Recording, and Reporting Photon-BeamIntensity-Modulated Radiation Therapy (IMRT) ICRU Report. 2010; 83,

Sanchez-Nieto, B. and Nahum, A.E. Bioplan: a software for the biological evaluation of radiotherapy treatment plans. 2000; Medical Dosimetry. 25 (2),.

Andrzej Niemierko, Reporting and Analyzing dose distributions: A concept of equivalent uniform dose,. 1997; Medical Physics 24(1), pp. 103-109,.

Brenner DJ. Dose, volume, and tumor-control predictions in radiotherapy. Int J Radiat Oncol Biol Phys.1993; Apr 30;26(1):171-9.

International Commission on Radiation Units and Measurements: Dose and Volume specification for reporting intracavitary therapy in gynecology. ICRU Report No. 38, 1985

Task group No. 43, Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Medical Physics. 1995; 22(2), pp. 209-234,


  • There are currently no refbacks.