Assessment of Risk Factor for Development of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetic Mellitus Patients of Raigarh Chhattisgarh

Dr. Harish Kumar Uraon, Dr. Onkar Kashyap, Dr. Deba Priya rath

Abstract


Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver diseases.  It is a histological spectrum of disease and includes the simple steatosis and NASH.  NAFLD may progress to cirrhosis, liver failure, and hepatocellular carcinoma. NAFLD is strongly associated to the features of metabolic syndrome. The purpose of this study was to identify the risk factor for development of Non-Alcoholic Fatty Liver Disease in Type 2 diabetic mellitus patients.

Aims & Objective:  To evaluate the various risk factor for development of NAFLD in Type2 diabetes mellitus patients.

Method: This study was done between May 2015 to June 2016 at the Department of Biochemistry, Late Shri Lakhiram Agrawal Memorial Medical College Associated KGH Raigarh CG. All patients attending the Medicine OPD & IPD for their blood pressure, Anthropometry, Biochemical parameters and Ultrasound abdomen was done. The data were analyzed using SPSS version 20. Descriptive statistics, correlation, regression and one way student’s t-test were performed for data analysis.

Results: NAFLD was observed in 52% of patients who had greater BMI (p < 0.001), 94% of hypertension with frequency (p<0.001). Metabolic syndrome was more frequent in those with NAFLD (p = 0.005). The mean levels of Triglyceride, FBS, PPBS, HBA1C, SGOT, ALP, Urea, Creatinine, T. Bilirubin, D. Bilirubin, Triglyceride, HDL, LDL and VLDL were significantly higher in patients with NAFLD than those without NAFLD (p<0.001). The mean value of Creatinine and ALP had significant correlation with age (p<0.01). Urea, Creatinine, SGOT and HDL showed significant correlation with Hb (p<0.01).

Conclusion: There is higher prevalence of all the components of metabolic syndrome in cases of NAFLD. Its early detection will help in modifying the disease course, delaying complications and will also play a major role in preventive cardiology. Almost half of patients with DM2 were found to have NAFLD, and they have more elevated BMI, as well as higher levels of Triglyceride, FBS, PPBS, HBA1C, SGOT, ALP, Urea, Creatinine, T. Bilirubin, D. Bilirubin, Triglyceride, HDL, LDL and VLDL than subjects without NAFLD.


Keywords


NAFLD, DM, BMI, SGOT, SGPT, HDLLDL

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