Significantly Enhanced MDA levels in Rheumatoid arthritis and Osteoarthritis cases as a measure of oxidative damage

Dr. Arshia Fatima, Dr. Mohd Ishaq

Abstract


The  main objective of the  study was to investigate  the ongoing free radical induce damage in Rheumatoid arthritis  and Osteoarthritis patients by measuring the  Malondialdehyde (MDA)  level with a view to  gain  insight into the pathogenesis of these disorders. A total of 131 RA patients and 47 OA patients were studied along with  95 healthy  controls were included  in the study. The Mean MDA level  in RA and OA patients were  509.20 ± 16.31 nmol/dl  and 514.18 ± 25.23 nmol/dl     respectively. These levels were significantly higher than that in the control  group  205.78±9.87 nmol/dl. The significance of increased lipid peroxidation as assessed by MDA level in these two clinical conditions has been discussed.


Keywords


Malondialdehyde, Rheumatoid arthritis, osteoarthritis

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References


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