LIPID PROFILE AND CARDIAC MARKERS IN PATIENTS OF MYOCARDIAL INFARCTION: A DEMOGRAPHIC STUDY WITH BIOCHEMICAL PERSPECTIVE IN INDIAN POPULATION

R D Yadav, Dr. Bankar Madhusudan P, Dr. Momin A A

Abstract


The vascular disorders are leading cause of death, with increase in prevalence of physical deformity, cardiovascular and cerebrovascular disorders worldwide. The myocardial infarction also called as heart attack that affects mainly cardiac muscle functions. There are several risk factors including biochemical, genetic and environmental that causes myocardial infarction, Therefore even after an advancement of diagnostic science, diagnosis of acute myocardial infarction is challenging because of its multiple etiology. In the present study the focus was the biochemical factors causing myocardial infarction and the cardiac markers. The concentrations of triglycerides, total cholesterol and HDL cholesterol were estimated from fasting serum samples, followed by the calculations of LDL & VLDL cholesterol and ratios viz. TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C. Also we have estimated the CK-MB, Troponin-I and Brain Natriuretic Peptide (BNP) levels. 150 acute myocardial infarction subjects along with 150 age and sex matched healthy controls were included in the present sutdy. Significantly higher levels of CK-MB, TnI and BNP were reported in AMI patients than controls. There was a significant increase in levels of triglyceride, total Cholesterol, LDL Cholesterol, VLDL Cholesterol, LDL-C/HDL-C, TC/HDL-C, TG/HDL ratios and decrease in HDL cholesterol was observed. Therefore it is suggestive to investigate the combination of lipid parameters with CK-MB, TnI and BNP levels, which will help in diagnosis of AMI with early signs.


Keywords


Acute myocardial infarction, Brain natriuretic peptide, Troponin I and CK-MB, lipid profile

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