CHANGE IN LIPID PROFILE AMONG ACUTE VIRAL HEPATITIS

Dr. Bashar Imam Ahmad, Dr. Muzaffari Yasmeen

Abstract


Background: liver is responsible for the metabolism of the lipid profile. In the cases of acute viral hepatitis the dysfunction of liver lead to dyslipidemia. Present study examined the plasma lipid profile in the cases of acute viral hepatitis.  

 Methods: This is the Hospital-based prospective study on acute viral hepatitis. Sixty cases of acute viral hepatitis and sixty age and sex matched controls was included in study. Routine biochemical investigation for viral marker lipid profile and liver function test was done in the positive viral hepatitis cases. A ‘p value’ <0.05 was considered statistically significant.

Results: no significant difference in the base line characteristic of the case and control (p>0.5).  Jaundice (100%),   anorexia (99%), vomiting (100 %) and dark coloured urine (100%) were the commonest presentations. Serum cholesterol, triglycerides, low density lipoprotein (LDL) were appreciably higher (p<0.01) while high density lipoprotein (HDL) was considerably lesser (p<0.01) in acute viral hepatitis compared to controls.

Conclusion Noteworthy variation of the lipid profile in blood is seen in the cases of acute viral hepatitis. Difference in lipid fractions point out the severity of the liver damage and help in prognosis of the Acute hepatitis patients.


Keywords


: Acute viral hepatitis, serum lipids, liver function test.

Full Text:

PDF

References


Bell AW: Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Progress in lipid research 1979, 18(3):117-164.

Jain P, Prakash S, Gupta S, Singh KP, Shrivastava S, Singh DD, et al. Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: A hospital based study. Indian J Med Microbiol 2013; 31:261-5.

Luo L, Pu X, Wang Y, Xu N. Impaired plasma lipid profiles in acute hepatitis. Lipids in health and disease. 2010; 9(1):1-6.

Tietge UJ, Boker KH, Bahr MJ, Weinberg S, Pichlmayr R, Schmidt HH, Manns MP: Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation. Hepato-gastroenterology 1998, 45(24):2255-2260.

Sherlock S: Alcoholic liver disease. Lancet 1995, 345(8944):227-229.

Prasanta Kumar Bhattacharya et al / Lipid profile in acute viral hepatitis: A study from north eastern India IJBAR (2016) 07 (08)

Irshad M, Singh S, Ansari MA, Joshi YK. Viral hepatitis in India: A Report from Delhi. Glob J Health Sci 2010; 2:96 103.

Flint A Jr: Experimental research into a new excretory function of the liver consisting in the removal of cholesterine from the blood and its discharge from the body in the form of stercorine. Am J Med Sci 1862; 44: 305–65.

Ahaneku JE, Olubuyide IO, Agbedana EO, Taylor GO. Changes in plasma high density lipoprotein cholesterol and phospholipid in acute viral hepatitis and cholestatic jaundice. Journal of Internal Medicine. 1991; 229(1):17-21.

Jorge AD, Ponce G, Milutin C, Sanchez D, Diaz M, Perez R, Esley C: [Importance of apolipoproteins A-1 and B in acute viral hepatitis and hepatic cirrhosis]. Acta gastroenterologica Latinoamericana 1986,

(1):39-46.

Vergani C, Trovato G, Delu A, Pietrogrande M, Dioguardi N: Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease. Journal of clinical pathology 1978,

(8):772-778.


Refbacks

  • There are currently no refbacks.