MORPHOMETRIC AND ELEMENTAL ANALYSIS OF A POLYMER BASED NANOPARTICLE- FLAVONOID ENCAPSULE

S. K. Sundar, Addala Lakshmi Bhavani

Abstract


In this study a polymer based  nanocarrier platform suitable for encapsulation of  a flavonoid Apigenin (DIONC – Apigenin) applicable for cancer therapy was developed and a morphometric and elemental analysis of the nanoparticle assembly  was done by SEM – EDS. The SEM reports showed that a net with tiny particle hanging on the polymer dextran coated nanocomposite, which reveals the embedding and incorporation of Fe3O4 nanoparticle in dextran polymer film, The iron oxide  nanoparticles increases the electrostatic surface area of the polymer dextran by increasing its folds and changing it into a net and  providing a favorable environment for trapping drugs inside it. In the elememtal maps C,O and Fe was deduced. The DIONC – Apigenin capsule were examined for particle size and zeta potential analysis. The average particle  diameter of the DIONC – apigenin capsule was 208.2nm and the zeta potential of dextran nanoparticle composite and flavonoid was found to be -18.7mV

Keywords


Iron Oxide Nano particle, Dextran, Apigenin, SEM, EDX

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References


Reis CP, Neufeld RJ, Ribeiro AJ, and Veiga F. Nanoencapsulation Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine,2006; 2: 8 - 21.

Gupta AK, Gupta M, Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials, 2005; 26(18): 3995-4021.

Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN, Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications. Chemical Reviews, 2008;108: 2064–110.

Laurent S, Boutry S, Mahieu I, Vander Elst V, Muller RN. Iron Oxide Based MR Contrast Agents: from Chemistry to Cell Labeling. Current Medicinal Chemistry, 2009; 16: 4712–27.

Xie J, Huang J Li. X , Sun S , Chen X. Iron Oxide Nanoparticle Platform for Biomedical

Applications." Current Medicinal Chemistry, 2009;16(10): 1278-1294.

Massart R. "Preparation of aqueous magnetic liquids in alkaline and acidic

media." Transactions on Magnetics, 1981;17(2): 1247-1248.

Bautista C, Bomati-Miguel M, Del Puerto O, Morales,M, Serna CJ & Veintemillas-Verdaguer S, Surface characterisation of dextran-coated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation. Journal of Magnetism and Magnetic Materials, 2005; 29:320-27.

Bertholon I, Vauthier C, Labarre D, Complement activation by core–shell poly (isobutylcyanoacrylate)–polysaccharide nanoparticles: influences of surface morphology, length, and type of polysaccharide. Pharm Res ,2006; 23: 1313–1323.

Durand A, Marie E, Rotureau E, Leonard M, Dellacherie E. Amphiphilic polysaccharides: useful tools for the preparation of nanoparticles with controlled surface characteristics. Langmuir, 2004; 20: 6956–6963.

McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res, 2006, 20: 519– 530.

Ariya Saraswathy SK, Nazer SS, Nim N, Armugam S, Shenoy SJ, Jaysree RS. Synthesis and characterization of dextran stabilized superparamagnetic iron oxide nanoparticles for invivo MR imaging of liver fibrosis. Jr. Carbohydrate polymers. 2014; 101(1) 760-768.

Addala Lakshmi Bhavani and Sundar SK, Investigation of the functional groups, molecular weight and topography of Pediococcus pentosaceus (PH3)polysaccharide.

International Research Journal of Natural and Applied Science .2016; Vol.3(12)


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