STUDY OF PERICARDIAL FLUID BIOCHEMISTRY FOR ESTIMATION OF TIME SINCE DEATH

Dr.Jayashree Deshkar, Dr.Snigdha Jain, Dr Aditya Brajendra kumar

Abstract


The estimation of time since death at the time of autopsy has been and remains to be one of the challenges to the Forensic Pathologist.A total of 100 study cases were randomly selected after screening. The pericardial fluid was examined biochemically for enzyme activity of Amylase, Creatine Kinase (CK), Gamma-glutamyl Transferase (GGT) and Lactate Dehydrogenase (LDH) enzymes by photoelectric colorimetry method. The enzyme activity levels so obtained were charted and statistically studied and graphical records obtained against known post-mortem interval. The data thus obtained was analysed with a view to ascertain whether such assays could be of any help to estimate time since death routinely. In this study we observed a positive correlation of all the four enzymes with the time elapsed after death of which rise in CK was found to be statistically significant

Keywords


Post-mortem interval (Time since death), Pericardial fluid, Enzyme activity, Amylase, Creatine Kinase (CK), Gamma-glutamyl transferase (GGT), Lactate Dehydrogenase (LDH)

Full Text:

PDF

References


Parikh CK. Parikh’s textbook of medical jurisprudence and toxicology- for classrooms and courtrooms. 6th ed. Delhi, India: Satish Kumar Jain for CBS publishers; 1999

Reddy KSN. The essentials of forensic medicine and toxicology: 29th ed. Hyderabad, India: K Suguna Devi; 2010.

Vij K. Textbook of Forensic Medicine and Toxicology: Principles and Practice. 4th ed. New Delhi; Elsevier: 2008.

Ganong WF. Review of medical physiology. 19th ed. Stamford, Connecticut: Appleton & Lange; 1999.

Guyton AC, Hall JE. Textbook of Medical physiology, 22nd ed. Singapore: Mc Graw Hill Int. Ed. Harcourt Asia PTE Ltd.; 2005 pg 590-4.

Stewart RH, Rohn DA, Allen SJ, Laine GL. Basic determinants of epicardial transudation. Am J Physiol 1997, 273: H1408-14

Gibson AT, Segal MB. A study of the composition of pericardial fluid, with special reference to the probable mechanism of fluid formation: J Physiol 1978 April; 277: 367–377.

Hansen JT, Koeppen BM. Netter’s Atlas of human physiology 1st ed, Icon learning systems LLC, a subsidiary of multimedia, New Jersy: 2002.

Golwalla AF, Golwalla SA. Golwalla, Medicine for students. 22nd ed. Mumbai, India, 2008. 871-4,390, 285-6, 47-92, 620-42, 92- 5,508,673


Refbacks

  • There are currently no refbacks.