Tahmasebi S, Adhami-Moghdam F


Aim: Valproate Sodium is a medication used to treat symptoms of epileptic patients. This drug is having certain side effects on visual system. The purpose of this research is to check the visual system, mainly retina of these patients using electrooculography (EOG).

Method: Thirty epileptic patients prescribed for sodium valproate treatment were selected for the purpose of present study.

EOG was recorded in total population. Arden index (AI) was measured in patients group. Same procedure was repeated for the normal group. The results obtained in two groups were compared to check for statistically difference in two groups.

Results: The two group’s i. e. case and control were matched demographically from age, sex and visual acuity point of view.

The AI was 2.26 ± 0.62 and 2.18 ± 0.59 in case and control groups respectively. The difference between two groups was not statistically significant (P>0.05).

Conclusion: From the results of present study it can be concluded that valproate sodium affect the retinal pigment epithelium layer of retina which can be proved by electrooculography.


Epilepsy, Sodium Valproate, Retinal Pigment Epithelium, Electrooculography

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