Dr. Deepak Jain, Dr. Disha Saxena, Dr. Manoj Yadav, Dr. Nityanand


PURPOSE: Macrocytic anemia is a state with mean corpuscular volume (MCV) more than 100fL. Various disease initially may present as
macrocytosis. Thus, a detailed evaluation is required in every case of macrocytic anemia.
MATERIAL AND METHODS: This study was conducted on 500 patients of macrocytic anemia at Pt. B. D. Sharma PGIMS, Rohtak. Patients
with any chronic medical illness were excluded.
RESULTS: Majority of cases belonged to age group of 15-29 years of age with male preponderance. Pancytopenia was the most common
hematological presentation. Megaloblastic anemia accounts for macrocytosis in 90% of the patients with MCV 110fL or more. Vitamin B12 was
deficient in 84.5% cases with megaloblastic anemia. Non-megaloblastic causes include liver disease, aplastic anemia etc.
CONCLUSION: This study concluded that megaloblastic anemia is the most common cause of macrocytic anemia and likelihood of
megaloblastic cause increases with MCV of >110fL.


Macrocytic Anemia, Megaloblastic, Pancytopenia

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