FINE NEEDLE ASPIRATION CYTOLOGY OF PALPABLE BREAST LUMPS WITH THEIR HISTOPATHOLOGICAL CORRELATION

Dr Zeenat Naseeruddin P, Dr Rameez N. Patvegar, Dr S. S. More

Abstract


BACKGROUND: Fine-needle aspiration cytology (FNAC) is still an important first line diagnostic procedure in developing countries. FNAC of
breast lesions is quite specific and sensitive investigation and the results are comparable to histopathology.Aim of study is to evaluate role of fine
needle aspiration cytology in the diagnosis of breast lesions and to compare the cytological findings with the histopathology wherever possible. In
addition the sensitivity, specificity and accuracy of FNAC in breast lesions are carried out.
MATERIAL METHODS &RESULT: The present study was carried out on 100 patients who presented with palpable lump in the breast
;irrespective of age and sex were included in the study from the district hospital of North Karnataka, over a period of 15 months.In 69 cases
,cytological diagnosis was correlated with histological findings .
RESULTS: There was preponderance of benign breast lesions: 55cases (79.71%) and malignant cases 14(20.29%) .In present study,sensitivity is
92.85%,specificity is 100% in diagnosisng malignant lesions,with accuracy of 98.48% .Positive predictive value is 100% and negative predictive
value is 98.11%.
CONCLUSION: With experienced hands, FNAC is safe, cost effective and a reliable technique for preoperative evaluation of palpable breast
lumps. FNAC features are more informative when combined with physical and radiology findings (Triple test).


Keywords


Breast, Cytology,Histology, FNAC, ICC,

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References


GLOBOCAN 2008 FACT SHEET 2010, Breast cancer incidence and

mortality worldwide 2008 summary.[2. Joshi A, Maimoon S. Limitations of fine needle aspiration cytology in subtyping breast malignancies- A report of three cases. J Cytol. 2007;24:203–6.

Kaufman Z, Shpitz B, Shapiro M, Runa R, Lew S, Dinbar A. Tripple approach in the diagnosis of dominant breast masses: Combined physical examination, mammography and fine needle aspiration. J Surg Oncol. 1994;56:254–7.

Skrbínc B, Babic A, Cúfer T, Us-Krásovec M. Cytological grading of breast cancer in Giemsa-stained fine needle aspiration smears. Cytopathology. 2001;12:15–25.

Masood S. Prognostic factors in breast cancer: use of cytologic preparations. Diagn Cytopathol. 1995 Dec;13(5):388-95.

The uniform approach to breast fine needle aspiration biopsy. A synopsis. Acta Cytol. 1996;40:1120–6.[PubMed]

Giuliano AE, Hunt KK, Ballman KV, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011; 305:569-575.

Brancato B, Zappa M, Bricolo D, et al. Role of ultrasound-guided fine needle cytology of axillary lymph nodes in breast carcinoma staging. Radiol Med. 2004;108:345-355.

Sapino A, Cassoni P, Zanon E, et al. Ultrasonographically-guided fine-needle aspiration of axillary lymph nodes: role in breast cancer management. Br J Cancer. 2003;88:702-706.

Schmidt RL, Witt BL, Lopez-Calderon LE, Layfield LJ. The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology: a systematic review and meta-analysis. Am J Clin Pathol. 2013;139:300-308.

Rapid on-site evaluation of fine needle aspiration specimens by cytology scientists: a review of 3032 specimens.Shield PW, Cosier J, Ellerby G, Gartrell M, Papadimos D.Cytopathology. 2014 Oct; 25(5):322-9. Epub 2014 May 20.

Abati A, McKee G. Grading of breast carcinoma in fine needle aspirationcytology. DiagnCytopathol 1998; 19:153-4.

Lingegowda JB, MuddeGowda PH, Ramakantha CK, Chandrasekar HR. Cytohistological correlation of grading in breast carcinoma. DiagnCytopathol 2011; 39:251-7.

Nizzoli R, Bozzetti C, Naldi N, Guazzi A, Gabrielli M, Michiara M, et al. Comparison of the results of immunocytochemical assays for biologic variables on preoperative fine-needle aspirates and on surgical specimens of primary breast carcinomas. Cancer. 2000;90:61–6.

Kempula Geethamala, Venkataramappa Srinivasa Murthy, Bangalore Ramalingiah Vani, Madireddi Sudha Rao, Malugnalli Uddappa Thejaswini, Krishnarajapet Padmanabha Padmaja. Comparison of Immunocytochemistry and Immunohistochemistry on Breast Carcinoma: A Boon or a Bane?

J Lab Physicians. 2017 Jan-Mar; 9(1): 5–10.

Singh R1, Anshu, Sharma SM, Gangane N Spectrum of male breast lesions diagnosed by fine needle aspiration cytology: a 5-year experience at a tertiary care rural hospital in central India. 2012 Feb;40(2):113-7.


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