HYPOTHESIS OF DEVELOPMENT OF PULMONARY VEIN IN HUMAN

Dr. Bhadreshkumar P Vaghela, Dr. Deepak S. Howale, Dr. Jayeshkumar P Vaghela

Abstract


Introduction: Hypothesis of different theories of development of the pulmonary vein
Methods: Study of various theories regarding the development of pulmonary vein available in current data is done. On the basis of these studies we
have developed new theory (TheoryNo.3).
Results: Human embryos between 24-34 days showed that common pulmonary vein develops as outgrowth from superior wall of left auricle on
medial side and unites with angioblastic plexus of developing lung bud. No evidence was found that vein connects directly with sinus venosus in
early stages and later shifts in position as atrial septum grows. Initially the early cardiac development is complicated because it is associated with
other processes of development such as embryonic folding of coelomic-cavity and vascular development. Due to this it is necessary to integrate
experimental and morphological analyses. Observational controversies are frequent rather than result from differences in interpretation. In
development of pulmonary vein and systemic venous sinus (sinus venosus), a 3D study in the chicken embryo of the developing venous pole shows
that pulmonary vein separates from a greater vascular plexus within splanchanic mesoderm. The development of systemic venous sinus at junction
between somatic and splanchnic mesoderm. Pulmonary vein in human heart originates from systemic venous sinus appears as new structure
draining to left atrium. In addition, we examined sequence of incorporation of the initially solitary pulmonary vein to the stage at which four
venous orifices opened to left atrium.
Discussion: According to Theory No-1&2, a development of single embryonic pulmonary vein as an outgrowth of posterior left atrial wall just to
left of septum primum.


Keywords


Pulmonary Veins, Splanchanic Plexus, Common Cardinal Venous System, Umbilicovitelline Venous System, Solitary Vein

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References


Neill CA. Development of the pulmonary veins; with reference to the embryology of anomalies of pulmonary venous return. Pediatrics 1956; 18:6,880-887.

Gert van den Berg, Antoon F. M. Moorman:Development of the Pulmonary Vein and the Systemic Venous Sinus: An Interactive 3D Overview Published: July 11, 2011

Moreno-Rodriguez RA, Krug EL, Reyes L, Villavicencio L, Mjaatvedt CH, et al. (2006) Bidirectional fusion of the heart-forming fields in the developing chick embryo. Dev Dyn 235: 191–202.

Colas JF, Lawson A, Schoenwolf GC (2000) Evidence that translation of smooth muscle alpha-actin mRNA is delayed in the chick promyocardium until fusion of the bilateral heart-forming regions. Dev Dyn 218: 316–330.

Sissman J (1966) Cell multiplication rates during development of the primitive cardiac tube in the chick embryo. Nature 210: 504–507.

Buckingham M, Meilhac S, Zaffran S (2005) Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6: 826–837.

Van den Berg G, Abu-Issa R, de Boer BA, Hutson MR, de Boer PA, et al. (2009) A caudal proliferating growth center contributes to both poles of the forming heart tube. Circ Res 104: 179–188.

De Jong F, Geerts WJC, Lamers WH, Los JA, Moorman AFM (1990) Isomyosin expression pattern during formation of the tubular chicken heart: a three- dimensional immunohistochemical analysis. Anat Rec 226: 213–227.

Kamino K, Hirota A, Fujii S (1981) Localization of pacemaking activity in early embryonic heart monitored using voltage-sensitive dye. Nature 290: 595–597

Van den Berg G, Moorman AF (2009) Concepts of cardiac development in retrospect. Pediatr Cardiol 30: 580–587.

Romanoff AL (1960) The avian embryo. Structural and functional development. New York: The Macmillan Company.

T W Salder:Langman’s Medical Embryology;12th edition;pp174 Development of The Venous System: The Portal System And Pulmonary VeinsReview of Medical Embryology Book By BEN PANSKY,

Seale A, Carvalho J, Gardiner H, Mellander M, Roughton M, Simpson J, et al. Total anomalous pulmonary venous connection: impact of prenatal diagnosis. Ultrasound Obstet Gynecol. 2012 Jan 20.

George A,Gregory&Dean B.Andropoulos:Wilky-Blackwell:Anasthesia with wilky Desktop edition :5th edition :page no:69

Hall SM, Hislop AA, Haworth SG (2002) Origin, differentiation, and maturation of human pulmonary veins. Am J Respir Cell Mol Biol 26: 333–340.

Rosenquist GC (1971) Pulmonary veins in the chick embryo: origin as determined by radioautographic mapping. Anat Rec 169: 65–69.

Sizarov A, Anderson RH, Christoffels VM, Moorman AF (2010) Three- Dimensional and Molecular Analysis of the Venous Pole of the Developing Human Heart. In press.

Webb S, Kanani M, Anderson RH, Richardson MK, Brown NA. Development of the human pulmonary vein and its incorporation in the morphologically left atrium.Cardiol Young. 2001 Nov;11(6):632-42. PubMed PMID: 11813915.

Soufan AT, van den Hoff MJB, Ruijter JM, de Boer PAJ, Hagoort J, et al. (2004) Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias. Circ Res 95: 1207–1215.

Webb S, Brown NA, Anderson RH, Richardson MK (2000) Relationship in the chick of the developing pulmonary vein to the embryonic systemic venous sinus. Anat Rec 259: 67–75.

Jongbloed MR, Mahtab EA, Blom NA, Schalij MJ, Gittenberger-de Groot AC (2008) Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. ScientificWorldJournal 8: 239–269.

Martin AW (1980) Some Invertebrate Myogenic Hearts: The Hearts of Worms and Mollluscs. In: Bourne GH, ed. Hearts and Heart-like Organs. Grenada, West Indies: Academic Press, INC. pp 11–39.

Farmer CG (1999) Evolution of the vertebrate cardio-pulmonary system. Annu Rev Physiol 61: 573–592

Edwards JE. Mayo Clin Proc 1953;28:441-452

Pediatr Clin North Am 1963;10:781-836


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