Dr Garima Sachdeva, Dr Shalini Gainder


OHSS, though a rare complication of ovarian stimulation, but if not detected early and adequately managed can lead to life threatening
Objective: To report a case of a variant of hypogonadotropic hypogonadism with severe OHSS and to discuss the risk factors and strategies of
Case report: Here, we present a case of hypogonadotropic hypogonadism with polycystic ovarian morphology. She was a thin built woman with
eight years of infertility. Her AMH value was on a higher side and on ovulation induction. She developed severe late onset OHSS on day 11 of the
HCG trigger which was successfully managed.
Conclusion: While doing ovulation induction in patients with hypogonadotropic hypogonadism, it should be kept in mind that there exists a
variant with polycystic ovarian morphology (PCOM), who might show hyper-response to gonadotropin stimulation. These are the patients who are
at high risk of OHSS and need more frequent monitoring. Serum AMH and polycystic morphology on stimulation can help suspect OHSS at an
early stage. Luteal coasting or use of progesterone’s in place of HCG for luteal phase support can help in decreasing the risk of severe OHSS.


OHSS, PCOS, Hypogonadism, AMH, HCG

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