EVALUATION OF THE EFFICACY OF TOPICAL FERACRYLUM SOLUTION (1%) AS A HAEMOSTATIC AGENT DURING MAJOR HEAD AND NECK SURGERY – A RANDOMIZED CONTROLLED STUDY.

Dr. Vani Mehrotra, Dr. Srivalli Natarajan

Abstract


Background: Limiting blood loss presents a challenge to the surgeon. An external, hemostatic agent – Feracrylum can be a good companion in
major head and neck surgeries.
Methods: Total Sample size was 30 patients undergoing major head and neck surgery. These patients were randomly assigned to either group A
(Feracrylum group, n = 15) or group B (normal saline group, n = 15).
Results: The mean difference in Haemoglobin values of group A and B were compared and greater drop were seen in group B as compared to group
A on postoperative day 2 and 5 (p = 0.229), and more number of patients had greater loss (>2gm %) in group B. The mean values of drain collection
were always more in group B when compared to group A
Conclusion: It was observed in this study that 1% Feracrylum solution led to decrease in blood loss from surgical wounds, though the results were
not statistically significant. It was found to be safe with no adverse effects on hepatic or renal parameters.


Keywords


1% Feracrylum Solution, Feracrylum Solution, Local Hemostatic Agent, Hemolok, Feracrylum.

Full Text:

PDF

References


Samudrala S. Topical hemostatic agents in surgery: a surgeon’s perspective. AORN J. 2008;88:S2-11.

Bochicchio G, Dunne J, Bochicchio K, Scalea T. The combination of platelet-enriched autologous plasma with bovine collagen and thrombin decreases the need for multiple blood transfusions in trauma patients with retroperitoneal bleeding. J Trauma. 2004;56(1):76-79.

Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004;91(5):851-860.

Tomizawa Y. Clinical benefits and risk analysis of topical hemostats: a review. J Artif Organs. 2005; 8(3):137-142.

Krebs VE, Higuera C, Barsoum WK, Helfand R. Blood management in joint replacement surgery: what’s in and what’s out. Orthopedics. 2006;29(9): 801-803.

Albala DM, Lawson JH. Recent clinical and investigational applications of fibrin sealant in selected surgical specialties. J Am Coll Surg. 2006;202(4): 685-697. Epub February 20, 2006.

Oz MC, Rondinone JF, Shargill NS. FloSeal Matrix: new generation topical hemostatic sealant. J Card Surg. 2003;18(6):486-493.

Tan SR, Tope WD. Effectiveness of Mecroporous polysaccharide Hemospheres for Achieving Hemostasis in Mohs Micrographic surgery, Dermatologic Survey. 2004;30,908-14.

Singh K, Dhruv K, Patle D, Paikra U. Role of local instillation of one percent feracrylum and haemocoagulase on wound healing. Int J Res Med Sci. 2016 Jan;4(1):169-176

Lahoti BK, Aggarwal G, Diwaker A, Sharma SS, Laddha A. Hemostasis during hypospadias surgery via topical application of feracrylum citrate: A randomized prospective study. J Indian Assoc Pediatr Surg 2010;15:87-9.

Tan SR, Tope WD. Effectiveness of Mecroporous polysaccharide Hemospheres for Achieving Hemostasis in Mohs Micrographic surgery, Dermatologic Survey. 2004;30,908-14.

Laddha AK, Mulla M, Sharma SS, Lahoti BK, Mathur R. A prospective comparison of topical feracrylum citrate versus adrenaline as haemostatic agent in hypospadias surgery in children. Afr J Paediatr Surg. 2014 Jul-Sep;11(3):215-8.

Shah NA,Gupta A, Patel D. A strategies to decrease blood loss in patients who undergo total knee replacement:a prospective study of one hundred and fifty cases.JISRF;2013(3):19-26.

Carless PA, Henry DA, Anthony DM. Fibrin sealant use for minimising peri-operative allogenic blood transfusion. Cochrane Database Syst Rev; 2003:CD004171.


Refbacks

  • There are currently no refbacks.