Dr. Subramaniam M Rao, Dr. Sharath K S, Dr. Darshan B Mundinamane


BACKGROUND: The primary goal of periodontal treatment is the maintenance of natural dentition in health and function. Present study was
under taken to evaluate the efficacy of PLA-PGA copolymer(Fisiograft®) gel in the treatment of infra-bony defects as compared with open flap
debridement alone.
METHODOLOGY: Ten patients, aged 25-50 years with moderate to severe periodontitis. Two or more sites with ≥5 mm probing depth(PD),
radiographic evidence of intra-osseous defects on opposite sides were selected. One defect was treated with Fisiograft® gel(Test), other with open
flap debridement alone(Control). At baseline, 3, 6, & 9 months clinical parameters and radiographs were evaluated and statistically analysed.
RESULTS: Study exhibited statistically no significant difference with both treatment modalities with all clinical parameters and radiographically
with the defect fill.
CONCLUSION: This study showed use of copolymer(Fisiograft®) gel did not provide additional benefits over open flap debridement.


Bone Grafts, Infrabony Defects, Periodontitis

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l. Meadows C L, Marlin EG, George Q, and Thomas ALA. Comparison of polylactic acid granules and of decalcified freeze-dried bone allograft in human periodontal osseous defects. J Periodontol 1993;64:103-109.

Stancari F, zami B, Bernardi F, Calandriello M, Salvatorelli G. Use of PLA-PGA (copolymerised polylactic/polyglycolic acids) as a bone filler: Clinical experience and histologic study of a case. Quintessenz(Germany)2000;51(1): 47-52.

Hollinger JO. Preliminary report on the osteogenic potential of abiodegradable copolymer of polylactide (PLA) and polyglycolide (PGA). JBiomed Mater Res 1983; 17(1):71-82.

GHIMAS, s.p.a.: Fisiograft product catalogue. Italy.

Edwards RC, Kiely KD and Eppley BL The fate of resorbable poly-L-lactic/polyglycolic acid (LactoSorb) bone fixation devices in orthognathicsurgery. J Oral Maxillofac Surg 2001; 59:19-25.

Bessho K, Iizuka T and Murakami K. A bioabsorbablepoly-L-lactideminiplate and screw system for osteosynthesisin oral and maxillofacialsurgery. J Oral Maxillofac Surg 1997; 55:941-945.

Zaffe D, Leghissa. G C, Pradelli J and BotticelliA R. Histological study onsinus lift grafting by Fisiograft and Bio-Oss. J Mater SciMaterMed. 2005; 16(9):789-793.

Clark DC, Quee TC, Bergeron MJ, Chan ECS, Lautar-Lemay C and de Gruchy K. Reliability of Attachment Level Measurements Using the Cementoenamel Junction and a Plastic Stent. J periodontol 1987; 58: 115-118.

Antezak-Bouckoms AA, Tulloch JFC and Berkey CS: Split-mouth and crossover designs in dental research. J Clin Periodontol 1990; 17: 446-453.

Pihlstrom BL: Measurement of Attachment Level in Clinical Trials: Probing Methods. J Periodontol 1992; 63: 1072-1078.

Watts T: Constant force probing with or without a stent in untreated Periodontal disease: the clinical reproducibility problem and possible source of error. J clin Periodontol 1987; 14: 407-411.

Eickholz P, Benn DK, Staehle HJ. Radiographic evaluation of bone regeneration following periodontal surgery with or without expanded polytetrafluoroethylene barriers. J Periodontol 1996; 67: 379-85.

Aichelmann-Reidy E M and Yukna R A: Bone replacement grafts-The bone substitutes DCNA 1998; 42(3): 491-503.

Trombelli L, Heitz-Mayfield L, Needleman I, Moles D, Scabbia A: A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol 2002; 29(3): 117-135.

Galgut PN, Waite IM, Brookshaw JD and Kingston C P. A 4-year controlled clinical study into the use of a ceramic hydroxylapatite implant material for the treatment of periodontal bone defects. J Clin Periodontol 1992; 19: 570-577.

Nasr FH, Aichelmann-Reidy E M and Yukna R A. Bone and bonesubstitutes. Periodontol 20001999; 36: 74-86.

Reynolds MA, Aichelmann-Reidy EM, Branch-Mays GL and Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systemic review. Ann Periodontol 2003; 8(l): 227-265.

Machtei E: Outcome variables for the study of periodontal regeneration. Ann Periodontol 1997; 2: 229-239

Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol 1996; 1: 621-6

Ezz, MN. Clinical and radiological evaluation of a synthetic copolymer as anaugmentation material in the immediate placement of a single dental implant. J Egypt Dent Assoc 2002; 48(2).

Scarano , Degidi M, Lezzi G, Pecora G, et al. Maxillary sinus augmentation with different biomaterials: A comparative histologic and histomorphometric study in man. Implant Dentistry 2006; 15(2):197-207.

Soliman MM, Zaki AA, Gazaerly HME, Shemmrani AA, Sorour AEL. Clinical and radiographic evaluation of copolymerized Polylactic/polyglycolic acids as a bone filler in combination with a cellular dermal matrix graft around immediate implants. Int JHealth Sci (Qassim).2014;8(4):381-92.

Jangid MR, Rakhewar PS, Nayyar AS, Cholepatil AR.Comparative evaluation of fisiograft (polylactic and polyglycolic acid co-polymer) with open flap debridement (OFD) versus open flap debridement (OFD) alone in the treatment of periodontal intra-bony defects: a clinical and radiographic study. J clin sci2017; 14(1): 42-48.

Minenna L, Herrero F, Sanz M and Trombelli L. Adjunctive effect of a polylactide/polyglycolide copolymer in the treatment of deep periodontal intra-osseous defects. A randomized clinical trial. J Clin Periodontol 2005; 32(5):456.

Pandey R, Madhumala R, Saranyan R, Sreekanth P. Use of Fisiograft in Intrabony Defects- A Clinical and Radiological Study. J Clin Diagn Res. 2013; 7(10): 2364-2367.


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