A COMPARITIVE STUDY OF CLINICAL FEATURES AND LABORATORY CHARECTERISTICS OF HISTOPATHOLOGICALLY CONFIRMED KIKUCHI VS NON KIKUCHI DISEASE AND TO EVALUATE THEIR USEFULLNESS IN THE DIAGNOSIS OF KIKUCHI-FUJIMOTO DISEASE.

Dr. R. Muthukrishnan, Dr. M. Indumathy, Dr. T. M. Karthikeshwaran, Dr. Harshavardhini S

Abstract


INTRODUCTION: Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease that mainly
affects young women. Patients present with localized lymphadenopathy, fever, and leukopenia in up to half of the cases. Kikuchi disease usually
gets better (resolves) on its own within one to four months (although it may take up to a year), with or without treatment. The primary threat is a
misdiagnosis of an infective, tuberculous or even a malignant pathology.
OBJECTIVES:To study of clinical features and laboratory characteristics of histopathologically confirmed Kikuchi vs non Kikuchi disease and
to evaluate their usefulness in the diagnosis of Kikuchi-Fujimoto disease.
METHODOLOGY: 160 cases of cervical lymphadenopathy between August 2013 and July 2018 were studied and the results analysed using Chi
square test.
CONCLUSIONS: Clinical features and lab parameters included in the study are significantly associated with presence of Kikuchi disease.


Keywords


Kikuchi-Fujimoto Disease (KFD), Lymphadenitis, Fine Needle Aspiration Cytology (FNAC), Histopathological Examination (HPE), Immunohistochemistry (IHC).

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References


Kuo T. Kikuchi's disease (histiocytic necrotising lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy. Am J SurgPathol 1995; 19:798-809. [Pubmed]

Hrycek A, Cieslik P, Witold S, Jacek P. Kikuchi-Fujimoto disease: a case report. RheumatolInt 2005 26:179-181. [Pubmed]

Cho KJ, Lee SS, Khang SK. Histiocytic necrotizing lymphadenitis. A clinico-pathologic study of 45 cases with in situ hybridization for Epstein-Barr virus and hepatitis B virus. J Korean Med Sci 1996; 11:409-414.

Hollingsworth HC, Peiper SC, Weiss LM, et al. An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease. Lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents. Arch Pathol Lab Med 1994; 118:134-140

Hrycek A, Cieslik P, Witold S, Jacek P. Kikuchi-Fujimoto disease: a case report. RheumatolInt 2005 26:179

Pileri S, Kikuchi M, Helborn D, et al. Histiocytic necrotising lymphadenitis without granulocytic infiltration. Virchows Arch A PatholAnatHistol 1982; 395:257-271. Pilichowska ME, Pinkus JL, Pinkus GS. Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease: lesional cell exibit an immature dentritic cell phenotype. Am J ClinPathol 2009; 131: 174-182)

Chamulak GA, Brynes RK, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J SurgPathol 1990; 14:514-523

Norris AH, Krasinskas AM, Salhany KE, et al. Kikuchi-Fujimoto disease: a benign cause of fever and lymphadenopathy. Am J Med 1996; 101:401-405.

Kikuchi M. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) in Japan. Am J SurgPathol 1991; 15:197-198.


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