A STUDY ON THE USEFULLNESS OF ACTIVATED LYMPHOCYTES AND LYMPHOCYTE COUNT IN PREDICTING EPSTEIN-BARR VIRUS INFECTIOUS MONONUCLEOSIS.

Dr. M. Indumathy, Dr. R. Muthukrishnan, Dr. T. M. Karthikeshwaran, Dr. Harshavardhini S

Abstract


INTRODUCTION: Infectious mononucleosis (IM) is caused by Epstein-Barr virus(EBV) commonly among adolescents and children presenting
with fever, malaise, sore throat, palatal petechiae, enlarged tonsils, cervical lymphadenopathy, lymphocytosis with atypical lymphocytes in blood,
hepatosplenomegaly, jaundice and rarely splenic rupture. The present study analysed the predictive diagnostic accuracy of total leucocyte count,
absolute lymphocyte count and percentage of atypical lymphocytes in the blood to diagnose IM
AIMS AND OBJETIVES:
Ÿ To evaluate the clinical usefulness and predictive value of blood parameters- lymphocytosis and presence of atypical lymphocytes in
diagnosing Infectious mononucleosis.
METHODOLOGY: This study was conducted among 898 patients with serological report for EBV, blood count reports, and with clinical signs &
symptoms suggestive of Infectious Mononucleosis over a 5 year period from January 2014 to August 2018.
CONCLUSION: Evaluation of blood parameters namely lymphocytosis, atypical lymphocytes, and WBC to lymphocyte ratio could significantly
help in the diagnosis of Infectious mononucleosis but cannot replace serology.


Keywords


Infectious mononucleosis (IM), Epstein-Barr virus (EBV), lymphocytosis, atypical lymphocytes, serological test (EBV- IgG-Elisa).

Full Text:

PDF

References


Jenson HB, Epstein Barr Virus, In: Kleigman RM, Stanton BF, St Geme J, Schor NF, ed. Nelson Textbook of Paediatrics, 20th edition. Philadelphia; WB Sanders 2015; 1586-1590

Dommerby H, Stangerup SE, Stangerup M, Hancke S. Hepatosplenomegaly in infectious mononucleosis, assessed by ultrasonic scanning. J LaryngolOtol 1986; 100:573-9.

Andersson JP. Clinical aspects of Epstein-Barr virus infection. Scand J Infect Dis Suppl 1991;80:94-104.

Aronson MD, Komaroff AL, Pass TM, Ervin CT, Branch WT. Heterophil antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med 1982; 96:505-8

Hoagland RJ. Infectious mononucleosis. Prim Care 1975; 2:295-307

Biggs TC, Hayes SM, Bird JH, Harries PG, Salib RJ. Use of the lymphocyte count as a diagnostic screen in adults with suspected epstein–barr virus infectious mononucleosis. The Laryngoscope. 2013 Oct;123(10):2401-4

Sumaya CV, Ench Y. Epstein-Barr virus infectious mononucleosis in children: I. Clinical and general laboratory findings. Pediatrics. 1985 Jun 1;75(6):1003-10

Tcherniaeva I, den Hartog G, Berbers G, van der Klis F. The development of a bead-based multiplex immunoassay for the detection of IgG antibodies to CMV and EBV. Journal of immunological methods. 2018 Jul 26.

Kasifoglu N, Oz S, Dinleyici EC, Us T, Bor O, Durmaz G, Akgun Y. Comparison of Methods Used for the Diagnosis of Epstein-Barr Virus Infections in Children. Polish Journal of Microbiology. 2018 Jan 1;67(1):81-8

Lennon P, O’Neill JP, Fenton JE, O’Dwyer T. Challenging the use of the lymphocyte to white cell count ratio in the diagnosis of infectious mononucleosis by analysis of a large cohort of Monospot test results. Clinical Otolaryngology. 2010 Oct;35(5):397-401.

O’Connor TE, Skinner LJ, Kiely P, Fenton JE. Return to contact sports following infectious mononucleosis: the role of serial ultrasonography. Ear Nose Throat J 2011;90:E21–E24.


Refbacks

  • There are currently no refbacks.