A STUDY OF ETIOLOGY AND CLINICAL PROFILE OF PANCYTOPENIA IN ADULTS

Divakar Kumar, Malyaban Das, Dr. Vidyapati, Prajit Mazumdar, Chandramani kumar

Abstract


background: pancytopenia is a relatively common hematological entity. it is a striking feature of many serious and life threatening illnesses. the
severity of pancytopenia and the underlying pathology determine the management & prognosis. thus identification of etiology will help for better
management and complete cure and better treatment of patients.
objectives:
1. to find out the underlying etiopathology of pancytopenia.
2. to study the clinical presentations in pancytopenia due to various causes.
methods: this study was a cross sectional study that was conducted at department of medicine of rajendra institute of medical sciences on one
hundred pancytopenia patients who were evaluated clinically, along with hematological parameters and bone marrow aspiration.
results: among 100 cases studied ,most patients presented with generalized weakness. the commonest physical finding was pallor followed by
splenomegaly and hepatomegaly. macrocytic anaemia was the predominant blood picture.. the commonest bone marrow finding
wasmegaloblastic erythroid hyperplasia. the commonest cause for pancytopenia was megaloblastic anemia (60%), followed by haematological
malignancy (20%) and aplastic anemia (12%). other causes of pancytopenia were hypersplenism, leishmaniasis.
conclusion: the commonest cause of pancytopenia in our study is megaloblastic anemia. this is in sharp contrast to the commonest cause of
pancytopenia in various studies throughout the world where aplastic anemia has been the most common cause.


Keywords


Aplastic Anaemia , Bone Marrow Aspiration, Megaloblastic Anemia, Pancytopenia.

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References


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