STUDY OF USG GUIDED FNAC IN THE DIAGNOSIS OF THYROID LESIONS PRESENTING AS SOLITARY NODULE WITH HISTOPATHOLOGICAL CORRELATION

Dr. Tulsi Chhadi, Dr Shyam Chhadi, Dr Kunal Chattani

Abstract


Background: Diagnostic workup in solitary thyroid nodule entails screening patients with high likelihood of malignancy. Large body of world
literature attests to the accuracy and advantages of FNAC.
Objective: To study cytological features of solitary thyroid nodules with ultrasound guided FNAC and studying the correlation of cytological
findings with histopathological findings.
Methodology: Fifty patients having solitary thyroid nodule underwent USG guided FNAC and histopathological examination during two years of
study period. Cytological features of solitary thyroid nodules were reported using Bethesda classification and the findings compared with
histopathological examination.
Observations: The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of USG guided FNAC in
solitary thyroid nodule evaluation were reported at 77.7%, 96.7%, 93.3%, 88.2% and 89.8% respectively. The Kappa statistic was 0.7725.
(p<0.001)
Conclusion: High correlation was observed between USG guided FNAC and histopathological examination for solitary thyroid nodule.


Keywords


FNAC, Solitary Thyroid Nodule, Histopathology

Full Text:

PDF

References


Hegedus L. Clinical practice: The thyroid nodule. N Engl J Med. 2004;351:1764-1771.

Vander JB, Gaston EA, Dawber TR. The significance of non-toxic thyroid nodule: Final report of a 15 year study of incidence of thyroid malignancy. Ann Int Med. 1968;69-537.

Dorairajan N, Jayashree N. Solitary nodule of thyroid and the role of FNAC in diagnosis. J Indian Med Assoc 1996;94(2):50-52.

Kaur K, Sonkhya N, Bapna AS, Mittal P. A comparative study of FNAC, Ultrasonography and radionuclide scan in the management of solitary thyroid nodule: A prospective analysis of fifty cases. Ind J Otolayrngol head neck surg. 2002 June;54(2):96-101.

Kumari K, Mrudula R. Solitary thyroid nodule: Cytopathology and histopathology. Eur J of Biomed and Pharmaceutical Sci. 2014;1(2):482-490.

Gupta M, Gupta S, Gupta VB. Correlation od fine needle aspiration cytology with histopathology in the diagnosis of solitary thyroid nodule. J Thyroid Res. 2010 Apr;18:47-51.

Cibas ES, Ali SZ. NCI Thyroid State of the Science Conference. The Bethesda System for Reporting Thyroid Cytopathology. Am J ClinPathol. 2009 Nov;132(5):658-65.

Arul P, Masilamani S. A correlative study of solitary thyroid nodules using the Bethesda system for reporting thyroid cytopathology. Journal of Cancer Research and Therapeutics. 2015 July-Sep;11(3):617-22.

Quddus MA, Allimuzzaman M, Sardar MKH. Role of FNAC in the evaluation of solitary cold thyroid nodule. J ShaheedSuhrawardy med Coll. 2012;4(1):15-17.

Wahid F, Khan FS, Ur Rehman H, Khan AI. Role of FNAC in diagnosis of solitary thyroid nodule. Iran J Otorhinolaryngol. 2011;23(65):111-18.

Sheikh WI, Alavi A, Raza W, Aurangazeb A, Ali F. Diagnostic accuracy of FNAC in solitary thyroid nodule. Journal of Rawalpindi Med Coll. 2011;15(2):82-83.

Basharat R, Bukhari MH, Saeed S, Hamid T. Comparison of FNAC and thyroid scan in solitary thyroid nodule. Pathlog Res Int. 2011;75:40-41.

Kessler A, Gavriel H, Zahav S, Vaiman M, Shlamkovitch N, Segal S et al. Accuracy and consistency of fine needle aspiration biopsy in the diagnosis and management of solitary thyroid nodules. Isr med Assoc Jour. 2005;7:371-73.


Refbacks

  • There are currently no refbacks.