Dr. Arpit Gohel, Dr. Kalpen Patel, Dr. Himil Parikh


Introduction: Celiac disease (CD) is the manifestation of an immune hypersensitivity reaction towards gluten in genetically predisposed
people(carriers of HLA-DQ2 and DQ8 haplotypes).It is characterized by inflammation of the small intestinal mucosa and progressive loss of
absorptive function. Clinical manifestations include gestrointestinal and systemic menifestations.
Aims & Objectives:The aim of the present study was to evaluation of histological diagnostic criteria for CD using two different grading methods
in duodenal biopsy .
Material &Method:Study was conducted at GCSMCH & RC by reviewing the records of 50 patients ,clinically suspected for CD, whose
duodenal biopsies received in pathology. Patients already treated for the same were excluded. 3 sections from each tissue block were stained with
H&E stain, diagnosis & staging was done according to Modified Marsh Oberhuber & Corrazza staging systems.
Results:Out of 50 patients, 28 were female and 22 were male(F:M Ratio1.27:1).Patients ranged in age group from 3-57 years. According to
Modified Marsh Oberhuber staging system & Corrazza staging system majority of patients staged as 3a [26 (52%)] & B1 [37 (74%)] respectively.
Conclusion: CD is commonly seen in female patients, though the reason for this is uncertain. According to both staging systems, presence of IEL is
the key feature. As duodenal biopsy is an important and safe means to identify underlying celiac disease, it should be routinely considered in all
patients undergoing endoscopic evaluation for clinical symptoms suggestive of CD.


Celiac Disease, Intra Epithelial Lymphocytes(iel),duodenal Biopsy

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Ian S. Brown, Jason Smith, Christophe Rosty ;Gastrointestinal pathology in celiac disease American Journal of Clinical Pathology,volume 138,issue 1,july 2012

Harrison’s Principles of Internal Medicine 19 th edition, volume 1,part 14 page no.1940.

B C Dickson , C J Streutker, R Chetty; Coeliac disease:an update for pathologists J ClinPathol. 2006 Oct; 59(10): 1008–1016. doi: 10.1136/jcp.2005.035345

Green PH Cellier C. Celiac disease;.N Engl J med.2007;357:1731-1743.

Rostami K Marsh MN.Diagnosis of coeliac disease;.Best Pract Res Cli Gastroenterol.2005;19:389-400

Collins MH ; Histopathology associated with eosinophiilic gastrointestinal diseases.IMMUNOL allergy CLIN north AM.2009;29:109-117,X-XI.

Walker smith JA, Guandanili S et al .Revised Criteria for Diagnosis of Coeliac Disease: Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition.Arch Dis Child. 1990 Aug;65(8):909-11.

Vitoria J C,Castano L, Rica I, Bilbao J R, Arrieta A, Garcia –Masdevall M D. ;Association of insulin dependant diabetes mellitus and celiac disease: a study based on serologic markers.J pediatr gastroenterol Nutr.1998;27:42-52.

Farre C, Humbert P,Vilar P,Vilar V, Aldeguer X .;serological markers and HLA-DQ2 haplotypes among first degree relatives of celiac patients. Catalonian coeliac disease study group.

Patterson RN ,Johnston SD.; Iron defeciency anaemia: are the British society of gastroenterology guidelines being adhered to Postgrad Med J.2003;79:228

Unsworth DJ, Lock RJ, Harvey RF. ;Improving the diagnosis of coeliac disease in Anaemic women.BR J Haematol.2000;111:898-901[pubmed]

Di Sabatino, A Corrazza GR.Coeliac disease.Lancet .2009;373:1480-1493.


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