CO-RELATION OF SERUM URIC ACID LEVELS IN ESSENTIAL HYPERTENSION

Dr. Amit Kumar

Abstract


Hypertension may be due to increased oxidative stress. As urate is natural anti-oxidant, increase in level of hypertension is a case or effect of raised
uric acid level. Aim of the present study was to evaluate serum uric acid levels in cases of Essential Hypertension and Aim: comparison with
normotensives (controls) in different grades of hypertension. Material and Methods: 100 subjects were observed out of which 50 were normal
healthy control groups and 50 were of Essential Hypertension. Hypertensive subjects were further subdivided into 2 groups based on the level of
BP(JNC-7). Results: Mean serum Uric Acid levels is found to be 4.844mg/dl in 50 controls and 5.728mg/dl in 50 cases of Essential Hypertension,
5.5238mg/dl in stage 1 hypertension(BP=140-159mmHg) and 5.8759 in stage 2 hypertension(BP>160mmHg). Conclusion: It is seen that
hypertension is related to rise in mean serum uric acid levels and this rise is directly related to severity of hypertension. Randomized control trials
need to be done to see whether lowering serum uric acid level will ameliorate the level of blood pressure.


Keywords


Hypertension,Uric Acid

Full Text:

PDF

References


Harrison’s Principles of Internal Medicine, McGraw Hill Education /19th Edition,2015. Hypertensive Vascular Disease: chapter 298:1612

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

DorairajPrabhakaran, Jeemon P, Ambuj Roy. Global Burden of Cardiovascular Disease: Current Epidemiology and Future Directions. Circulation. 2016;133:1605-1620.

Ganong. Cardiovascular Regulatory Mechanism: Review of Medical Physiology/ McGraw Hill Medical Publishers/23rd Edition, Chapter 33.

Becker BF(June 1993) Towards the physiological function of uric acid.

Mazzali M et al. Uric acid and hypertension: cause or effect? CurrRheumatol Rep.2010 Apr;12(2):108-17. doi: 10.1007/s11926-010-0094-1.


Refbacks

  • There are currently no refbacks.