“A RETROSPECTIVE COHORT STUDY ON TREATMENT OUTCOME FOR MDR-TB UNDER DOT- PLUS PROGRAM”

Dr. Ashok Pralhad Waghmare

Abstract


BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR- TB) are the major public
health problem that threatens the progress in disease care and control worldwide. The treatment of MDR-TB with second line drug is prolonged,
complex, and expensive, having high rate of mortality along with the considerable rate of adverse effects. But the treatment efficacy rates in MDRTB
are the key issue that cannot be ignored and this present study aims to evaluate the treatment outcomes and potential factors associated in
patients with MDR-TB infections.
METHOD: - A retrospective cohort study was carried out among the enrolled in DOTS-Plus program with MDR-TB are 287 no. of patients from
2012 to 2018 in Tuberculosis department, Ashwini Rural Medical College Hospital and Research Centre Kumbhari, Solapur, Karnataka, India. The
patients necessary information such as demographics, clinical parameters, if any previous TB treatment history and treatment outcomes to Cat IV
anti-TB therapy, any interruptions in treatment, adverse drug reactions, culture conversion etc. were evaluated from the records.
RESULTS: Out of 287 patients, 32 (11.15%) had a successful cured after complete course of ATT). Remaining 153 patients had an unsuccessful
outcome (death (27.53%), default (20.56%), failure or switched to Cat V (5.23%), and 75 patients (25.09%) are on treatment.
CONCLUSION:-The treatment success rate revealed that MDR TB patients has shown low treatment success rate. Patients still on treatment and
High default treatment percentage had been observed, which could be the possible reason.


Keywords


Multidrug-resistant Tuberculosis (MDR-TB), Extensively Drug-resistant Tuberculosis (XDR- TB), Second-line Drugs, Treatment Outcome.

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