URINARY PROTEIN CREATININE INDEX IN PATIENTS WITH URINARY TRACT INFECTION

Rajesh Solanki, Madhuri Gupta, R.C. Gupta

Abstract


Background: Urinary tract infection (UTI) is defined as the presence of microbial pathogens in the urinary tract with associated symptoms. In
urinary tract infection, proteins are qualitatively non-detectable in urine. Raised excretion of proteins could be detected by measuring proteins in
24-hour urine. There are problems in collection of 24-hour urine sample. As an alternative, urinary protein to creatinine index (PCI) has been
devised to detect minor proteinuria in random urine samples.
Aim: The aim of the study was to assess whether urinary PCI can be used to detect minor proteinuria in patients with urinary tract infection.
Material and Methods: Twenty five patients with UTI who fulfilled the criteria comprised the study group and twenty-five age matched healthy
subjects were taken as a control group. Spot urine samples for quantifying urinary PCI were obtained. Sulfosalicylic acid method was used to
estimate urinary protein. The modified Jaffe's method was employed to estimate urinary creatinine. The urine protein: creatinine index was
calculated by dividing the urine protein concentration (mg/L) by urine creatinine concentration (mmol/L) multiplied by 10.
Results: Protein: creatinine index was found to be significantly higher in UTI (680+168.41) as compared to the control group (201.21+28.37).
Qualitative tests for patients were negative in all UTI patients.
Conclusion: The results show that random urinary PCI can be a good indicator of proteinuria in UTI patients. This test could be a reasonable
alternative to 24-hour urine sample collection for the detection of proteinuria in UTI patients.


Keywords


UTI, Protein Creatinine Index, Microproteinuria

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