ROLE OF NATURAL ANTIOXIDANT IN BREAST CANCER PATIENTS

Dr. Milind Dudhane, Dr. Rinku Bansal

Abstract


Background: Breast cancer is a nonexistent entity for a majority of population till a near and dear one suffers from it.
Introduction: Breast cancer is now the most common cancer in most cities in India, and 2nd most common in the rural areas.
Material and Methods: This prospective study was carried out in Obstetrics and Gynecology, oncology and biochemistry department of Annanta
institute of medical sciences, Udaipur ,India. 100 subjects with 100 controls were enrolled for the study.
Results: we have found decreased level of antioxidant in patients in comparison to control.
Conclusion: Awareness with supplementation of natural antioxidant is beneficial to prevent the risk of Brest cancer


Keywords


Breast cancer, cancer, antioxidant vitamin C, vitamin E.

Full Text:

PDF

References


Costa FF. Epigenomics in cancer management. Cancer Manag Res. 2010; 2:255-65.

Incidência de Câncer no Brasil. Estimativa 2014. Available from: http://www. inca.gov.br/estimativa/2014/estimativa-24042014.pdf.

Subramani T, Yeap SK, Ho WY, Ho CL, Omar AR, Aziz SA, et al. Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen. J Cell Mol Med. 2014; 18(2):305-13.

Fromberg A, Gutsch D, Schulze D, Vollbracht C, Weiss G, Czubayko F, et al. Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer ChemotherPharmacol. 2011; 67(5):1157-66.

Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S. Pharmacologic doses of ascorbic acid repress specificity protein (sp) transcription factors and sp-regulated genes in colon cancer cells. Nutr Cancer. 2011; 63(7):1133-42.

Park S. The effects of high concentrations of vitamin C on cancer cells. Nutrients. 2013; 5(9):3496-505.

Zaidi SM, Banu N. Antioxidant potential of vitamins A, E and C in modulating oxi-dative stress in rat brain. ClinicaChimicaActa, 2004;340:229–233.

Pace A, Savarese A, Picardo M et al. Neu-roprotective effect of vitamin E supple- mentation in patients treated with cisplatin chemotherapy. Journal of Clinical Oncology, 2003;21:927–931.

PDF | Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy.. Availablehttps://www.researchgate.net/publication/49727542_Effect_of_vitamins_C_and_E_on_antioxidant_status_of_breast-cancer_patients_undergoing_chemotherapy [accessed Jul 05 2018].

Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free RadicBiol Med. 2010; 49(1):1603-16.

Rajakumar T, Pugalendhi P, Thilagavathi S. Dose response chemopreventive potential of allylisothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. ChemBiol Interact. 2015; 231:35-43.

Guerriero E, Sorice A, Capone F, Napolitano V, Colonna G, Storti G, et al. Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines. PloS One. 2014; 9(12):e115287.

PDF | Vitamin E and breast cancer: A review. Available from: https://www.researchgate.net/publication/14096262_Vitamin_E_and_breast_cancer_A_review [accessed Jul 05 2018].

Reynolds, P. J Mammary Gland BiolNeoplasia (2013) 18: 15. https://doi.org/10.1007/s10911-012-9269-x

California Environmental Protection Agency. Health Effects of Exposure to Environmental Tobacco Smoke. Sacremento CA: California Environmental Protection Agency, Office of Environmental Health Hazard Assessment; 1997.

Seifried HE, McDonald SS, Anderson DE, Greenwald P, Milner JA. The antioxidantconundrum in cancer. Cancer Research, 2003;63:4295–4298.

Ceylan BG, Nazırog˘lu M, Ug ˘uz AC, Barak C, Erdem B, Yavuz L (2010) Effects of Vitamin C and E Combination on Element and Oxidative Stress Levels in the Blood of Operative Patients Under Desflurane Anesthesia. Biological Trace Element Research, doi: 10.1007/s12011-010-8712-3.

Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy.. Available from: https://www.researchgate.net/publication/49727542_Effect_of_vitamins_C_and_E_on_antioxidant_status_of_breast-cancer_patients_undergoing_chemotherapy [accessed Jul 06 2018].

Khan N, Afaq F, Mukhatr H. Cancer che- moprevention through dietaryantioxidants: progress and promise. Antioxidants & Redox Signaling, 2008;10:475–510.


Refbacks

  • There are currently no refbacks.