“EFFECT OF AGE ON LIPID PROFILE IN CHRONIC KIDNEY DISEASE’’

Manpreet Saini, Gurpreet Kaur, Nita Garg

Abstract


Aim: The aim of this study was to establish a correlation & find effect of Age on Serum T.Cholestrol, HDL,LDL,VLDL, TG, T.Cholestrol/HDL
ratio & LDL/HDL ratio of Chronic kidney disease patients.
Study Design: A hospital based Non-Experimental Observational Cross-sectional & Correlation Study was conducted on patients of both sex
attending the Out Patient Department & In Patient Department of Nephrology & Medicine of SMI Hospital, P.Nagar Dehradun for a period of 4
months from January 2014 to April 2014. Study comprises 54 Chronic kidney disease patients which were divided into five age groups i-e Age
group- 15-29yrs, Age group- 30-44yrs, Age group-45-59yrs, Age group- 60-74yrs, Age group- ≥75yrs. Inclusion criteria was patients with
evidence of Chronic kidney disease selected randomly of both sex & age above 15 years. Exclusion criteria was age <15 years & those not willing to
participate.
Methdology: Consecutive sampling technique & Bio-physiological method of collection of Data was used .5ml blood was collected in sterile
tubes from the fasting (8-12hrs) Chronic Kidney Disease patients & was analyzed for Serum T.Cholestrol, HDL,LDL,VLDL, TG,
T.Cholestrol/HDL ratio & LDL/HDL ratio by enzymatic method using VITROS ECIQ,an auto analyser at SMI Hospital, P.Nagar, Dehradun.
Correlation coefficient i-e r-value & p-value was analysed using Microsoft office Excel 2007. Positive r- value represented positive correlation
between that age group & that parameter & vice versa. P<0.05 was considered significant & P<0.01was considered highly significant
Results: Age group 15-29yrs was found to have negative Correlation coefficient with S. HDL,VLDL,TG, T.chol/HDL, LDL/HDL & positive
Correlation coefficient with T.Chol, LDL values of Chronic kidney disease patients. Relationship of HDL,VLDL,TG,T.Chol/HDL was found to be
Non significant (P>0.05) & S. T.Chol, LDL, LDL/HDL was found to have significant (P<0.05) relationship with this Age group.
Age group 30-44yrs was found to have negative Correlation coefficient with S. HDL,T.Chol,VLDL,TG, & positive Correlation coefficient with
T.chol/HDL, LDL/HDL, LDL values of Chronic kidney disease patients. Relationship of HDL,VLDL was found to be Non significant (P>0.05) &
S. T.Chol, TG was found to have significant (P<0.05) relationship, LDL,T.Chol/HDL,LDL/HDL ratio was found to have Highly significant
(P<0.01) relationship with this age group.
Age group 45-59yrs was found to have negative Correlation coefficient with S.T.Chol,LDL, T.Chol/HDL,LDL/HDL, & positive Correlation
coefficient with HDL,TG, VLDL values of Chronic kidney disease patients. Relationship of S. T. Chol, LDL,VLDL,TG, T.ChoL/HDL, LDL/HDL
was found to be Non significant (P>0.05) & HDL was found to have Highly significant (P<0.01) relationship with this age group.
Age group 60-74yrs was found to have negative Correlation coefficient with HDL, & positive Correlation coefficient with S.T.Chol, LDL,VLDL,
TG, T.Chol/HDL,LDL/HDL ratio values of Chronic kidney disease patients. Relationship of S. T.Chol,LDL,VLDL,T.ChoL/HDL,LDL/HDL was
found to be Non significant (P>0.05) & HDL,TG was found to have Highly significant (P<0.01) relationship with this age group.
Age group ≥75yrs was found to have negative Correlation coefficient with S.T.Chol, LDL,TG, T.Chol/HDL,LDL/HDL ratio & positive
Correlation coefficient with HDL,VLDLvalues of Chronic kidney disease patients. Relationship of LDL,VLDL,T.ChoL/HDL,LDL/HDL was
found to be Non significant (P>0.05) & S. T.Chol HDL,TG was found to have Highly significant (P<0.01) relationship with this age group.


Keywords


Chronic Kidney Disease, Age Group, T.cholestrol.

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