Mr. Amos Gelbard


Background: This article aims to explain the process in which Cortisol, known as the "Stress Hormone", designated to allow the transfer of
glucose from the body to the blood stream to respond to stressful situations, is the cause for several key illnesses, among them Alzheimer's Disease
and Diabetes, hypertension and schizophrenia.
This study will use past literature and connect the dots regarding the mechanism in which these illnesses work and explain why the way to
downgrade cortisol levels and therefore to possibly prevent or even cure these diseases, is by absorption of vitamin B12 and Folic acid through
nutrition or food supplementation.
Through analysis of previously researched literature this study will reach conclusions not previously discussed. It will use previous essays and
researches to support its theory and take them a step further to thoroughly explain the mechanisms and possible therapeutic strategies deriving from
Methods: The research relies on theory and analysis based on multiple previous studies referenced and quoted
Results: In AD, Diabetes and Hypertension high cortisol levels correlate with low folate and vitamin b12 levels and with high homeocysteine
Conclusions: A preventive and a possible treatment to AD and Diabetes as well as to other diseases explained is by consumption of folic acid and
viamin b12


Cortisol, Alzheimer's disease, Diabetes, Folic Acid, Folate, Vitamin B12

Full Text:



Amos Gelbard. ‘Glucose Role in Treatment of Alzheimer’s Disease’. Zefat Academic College, Zefat, Israel. 2016

Amos Gelbard. ‘Rethinking Glucose role in treatment of Alzheimer’s Disease based on the disease incidence in Diabetes type2 Patients’.ZefatAdademic College,Zefat, Israel. 2017

Amos Gelbard. 'Cortisol and Folate and their Roles in Alzheimer’s Disease, Diabetes'. ZefatAdademic College, Zefat, Israel. 2017

Amos Gelbard. ‘Discussion about Insulin Role in Diabetes Treatment’.ZefatAdademic College,Zefat, Israel. 2017

IacopoChiodini, Guido Adda, Alfredo Scillitani, Francesca Coletti, Valentina Morelli, Sergio Di Lembo, Paolo Epaminonda, BenedettaMasserini, Paolo Beck-Peccoz, EmanuelaOrsi, Bruno Ambrosi and Maura Arosio. 'Cortisol Secretion in Patients with Type 2 Diabetes: Relationship with chronic complications'. Milan, Italy. 2007

Hinterberger M, Zehetmayer S, Jungwirth S, Huber K, Krugluger W, Leitha T, Krampla W, Tragl KH, Fischer P. ‘High cortisol and low folate are the only routine blood tests predicting probable Alzheimer's disease after age 75-results of the Vienna Transdanube Aging Study.’ Vienna, Austria. 2013

Robert Clarke, MD; A. David Smith, DPhil; Kim A. Jobst. ‘Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease’. Oxford, England; Bergen, Norway. 1998

UndurtiN.Das. ‘Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease—But how and why?’. Ohio, USA. 2007

Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, MiaoyanZheng, Meilin Zhang, WeiliXu, and Guowei Huang. ‘Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial’. China. 2016

María M. Corrada, Claudia H. Kawas, Judith Hallfrisch, Denis Muller and Ron Brookmeyere. 'Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging'. Maryland, California; USA. 2005

Terzolo M, Allasino B, Bosio S, Brusa E, Daffara F, Ventura M, Aroasio E, Sacchetto G, Reimondo G, Angeli A, Camaschella C. ‘Hyperhomocysteinemia in patients with Cushing's syndrome.’ Torino, Italy. 2004

AnvitaKalea, NileshNaphadeb, Swati Sapkaleb, MarellasvKamarajub, AnilkumarPillaic, SadhanaJoshia, SahebaraoMahadik. ‘Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: Implications for altered one-carbon metabolism’. USA; India. 2009

Arduino A. Mangoni, Roy A. Sherwood, Belinda Asonganyi, Cameron G. Swift, Stephen Thomas, Stephen H.D. Jackson. ‘Short-Term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes’. American Journal of Hypertension. 2005

R. van Etten; de Koning, E; Verhaar, M; Gaillard, C; Rabelink, T. ‘Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate’. Utrecht, The Netherlands. 2002

M. Paul Murphy and Harry LeVine, III. 'Alzheimer’s Disease and the β-Amyloid Peptide'. Kentucky, USA. 2010

Epis R, Marcello E, Gardoni F, Di Luca M.'Alpha, beta-and gamma-secretases in Alzheimer's disease.' Milano, Italy. 2012

Strooper BD, Vassar R, Golde T. 'Thesecretases: enzymes with therapeutic potential in Alzheimer disease.' Nat Rev Neurol 6: 99-107. Leuven, Belgium. 2010

Dong H, Csernansky. 'Effects of Stress and Stress Hormones on Amyloid¬β Protein and Plaque Deposition'. J Alzheimers Dis 18: 459-469. Chicago, USA. 2009

.Csernansky JG, Dong H, Fagan AM, Wang L, Xiong C, et al, 'Plasma cortisol and progression of dementia in subjects with Alzheimer¬type dementia'. Am J Psychiatry 163: 2164-2169. St. Louis, USA. 2006

.Swaab DF, Raadsheer FC, Endert E,Hofman MA, Kamphorst W, et al. 'Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid.' J Neuroendocrinol 130: 1707-1712. Amsterdam, The Netherlands. 1994.

Mario Barbagallo and Ligia J Dominguez. 'Type 2 diabetes mellitus and Alzheimer’s disease'. Palermo, Italy. 2014

Gejl M, Gjedde A, Egefjord L, Moller A, Soren B, et al. 'In Alzheimer’s Disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: Randomized, placebo-controlled, double-blind clinical trial'. Aging Neurosci 8: 108. Denmark. 2016

Bak AM, Egefjord L, Gejl M, Steffensen C, Stecher CW, et al. 'Targeting amyloid-beta by glucagon-like peptide-1 (GLP-1) in Alzheimer's disease and diabetes'. Aarhus, Denmark. 2011's_disease_and_diabetes

VA, H ölscher C. 'GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid'. Eur J Pharmacol 587: 112-117. Northern Ireland, United Kingdom. 2006

Hsu, Chih-Cheng;,Wahlqvist, Mark L. Lee, Meei-Shyuan Tsai, Hsin-Ni. 'Incidence of Dementia is increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin'. Zhunan, Tawiwan. 2010

Hau Liu,Dena M. Bravata,JoselCabaccan,Hershel Raff,Elisabeth Ryzen. 'Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans'. Stanford, USA.

T. Ikeda,Y. Furukawa, S. Mashimoto, K. Takahashi,M. Yamada. 'Vitamin B12 levels in serum and cerebrospinal fluid of people with Alzheimer's disease'. Yamaguchi University, Japan. 1990

H-X. Wang, BA, Å. Wahlin, PhD, H. Basun, MD, PhD, J. Fastbom, MD, PhD, B. Winblad, MD, PhD and L. Fratiglioni, MD, PhD.'Vitamin B12 and folate in relation to the development of Alzheimer’s disease'. Stockholm, Sweden. 2001

Nisha G. Kemse, Anvita A. Kale, and Sadhana R. Joshi.'A Combined Supplementation of Omega-3 Fatty Acids and Micronutrients (Folic Acid, Vitamin B12) Reduces Oxidative Stress Markers in a Rat Model of Pregnancy Induced Hypertension'. India; USA. 2014

Medha N.Munshi, AngieStone, LouisFink, VivianFonseca.'Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease'. Arkansas, USA. 1996

Anoop Misra, Naval K. Vikram, R. M. Pandey, Manjari Dwivedi, Faiz Uddin Ahmad, Kalpana Luthra, Kajal Jain, Nidhi Khanna, J. Rama Devi, Rekha Sharma andRandeep Guleria. 'Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India'. India, 2014

Manuel R. Malinow, M.D., Paul B. Duell, M.D., David L. Hess, Ph.D., Peter H. Anderson, Ph.D., Warren D. Kruger, M.D., Beverley E. Phillipson, M.D., Robert A. Gluckman, M.D., Peter C. Block, M.D., and Barbara M. Upson, B.S.'Reduction of Plasma Homocyst(e)ine Levels by Breakfast Cereal Fortified with Folic Acid in Patients with Coronary Heart Disease'. New England Journal Medicine, 1998

Whitworth JA, Brown MA, Kelly JJ, Williamson PM. 'Mechanisms of cortisol-induced hypertension in humans'. Kogarah, Australia. 1995

Kelly JJ, Mangos G, Williamson PM, Whitworth JA.'Cortisol and hypertension'. Sydney, Australia. 1998

Xudong Mao, MD, Xubin Xing, MD, Rong Xu, MD, Qing Gong, MD, Yue He, MD, Shuijun Li, MD, Hongfu Wang, MD, Cong Liu, MD, Xin Ding, MD, Rishu Na, MD, Zhiwen Liu, MD, and Yi Qu, MD and Yung-Hsiang Chen. 'Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients With Type-2 Diabetes Mellitus, Hypertension, or Cardiovascular Disease'. Shanghai, China. 2016

Tamai Y, Wada K, Tsuji M, Nakamura K, Sahashi Y, Watanabe K, Yamamoto K, Ando K, Nagata C. 'Dietary intake of vitamin B12 and folic acid is associated with lower blood pressure in Japanese preschool children'. Japan. 2011

E P Quinlivan, J McPartlin, H McNulty, M Ward, J J Strain, D G Weir, J M Scott.'Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease'. 359: 227–228. Lancet. 2002

Cristiana Catena, GianlucaColussi, Francesca Nait, FrineCapobianco, Leonardo A. Sechi; Elevated Homocysteine Levels Are Associated With the Metabolic Syndrome and Cardiovascular Events in Hypertensive Patients, American Journal of Hypertension, Volume 28, Issue 7, 1 July 2015, Pages 943–950,


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