Debasis Dhar, Parthasarathi Ghosh, Saibal K Mukherjee, Sushil K Paira, Ramanuj Mukherjee, Sandip K Halder


We conducted anprospectivenonrandomizedinterventional study to compare the efficacy of a newer therapeutic agent Centchroman with established therapeutic agents Danazol and Evening Primrose Oil ( EPO ) in the treatment of mastalgia and fibroadenoma.Total 117 patients have been participated in the study (mastalgia-68, fibroadenoma-54 and 5 patients have both). In mastalgia group 28 ,18 and 22 patients were treated with Centchroman, Danazol and EPO respectively. In fibroadenoma group 17 ,18 and 19 patients received Centchroman, Danazol and EPO respectively. Centchroman was found to be the most effective drug with the post intervention pain scores <2 in 71% patients (50% with Danazole , 0% with EPO). In fibroadenoma group complete response rate was highest in Centchroman arm (29%)  in comparison to Danazol (17 %) and EPO (0%) respectively. Side effects are maximum with Danazole and Centchroman is the cheapest.


Centchroman, Danazol, EPO, Mastalgia, Fibroadenoma

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Deborah NA, Craig DS. Update on clinical and research issues in cyclical mastalgia. The Breast Journal 1998; 4(1):25-32

Smith RL, Pruthi S, Fitzpatrick LA. Evaluation and Management of Breast Pain.Mayo Clin Proc. 2004;79:353-372

PastaV, Dinicola S, Giuliani A, Harrath AH, Alwasel SH, Tartaglia F, Cucina Aand Bizzarri M. A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women. Breast Cancer: Basic and Clinical Research 2016;10: 37–43 doi:10.4137/BCBCR.S38408.

Soltany S, Toussy JA. The Effect of Vitamin B6 on Cyclic and Non-Cyclic Mastalgia. Adv. Environ. Biol.2014; 8(6) : 2936-2939

Goehring C, Morabia A. Epidemiology of Benign Breast Disease, with Special Attention to Histologic Types. Epidemiol Rev 1997; 19(2):310-27

Murshid KR. A review of mastalgia in patients with fibrocystic breast disease. J T U Med Sc 2011; 6(1):1-18

Thakur N, Zargar B, Nazeer N, Parray F, Wani R. Mastalgia – Use Of Evening Primrose Oil In Treatment Of Mastalgia. The Internet Journal of Surgery. 2009 ; (2).

Srivastava A, Mansel RE, Arvind N, Prasad K, Dhar A, Chabra A.Evidence-based management of Mastalgia: a meta-analysis of randomised trials.Breast. 2007 Oct;16(5):503-12.

Qureshi S, Sultan N. Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia.Surgeon. 2005 Feb;3(1):7-10.

Maddox RP, Mansel RE. Management of Breast Pain and Nodularity : World J. Surg. 1989; 13:699-705.

Blommers J, de Lange-De Klerk ES, Kuik DJ, Bezemer PD, Meijer S. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial.Am J Obstet Gynecol. 2002 Nov;187(5):1389-94.

Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, Bauer BA. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study.Altern Med Rev. 2010 Apr;15(1):59-67.

Greenblatt RB, Dmowski WP, Mahesh VB, Scholer HF. Clinical studies with an antigonadotropin-Danazol.Fertil Steril. 1971 Feb;22(2):102-12.

Greenblatt B, Ben-Nun I.Danazol in the treatment of mammary dysplasia.Drugs. 1980 May;19(5):349-55.

Nezhat C, Asch RH, Greenblatt RB. Danazol for benign breast disease.Am J Obstet Gynecol. 1980 Jul 1;137(5):604-7.

Gorins A, Perret F, Tournant B, Rogier C, Lipszyc J. A French double-blind crossover study (danazol versus placebo) in the treatment of severe fibrocystic breast disease.Eur J Gynaecol Oncol. 1984;5(2):85-9.

Andrews WC. Hormonal management of fibrocystic disease of the breast.J Reprod Med. 1990 Jan;35(1 Suppl):87-90.

Mansel RE, Wisbey JR, Hughes LE. Controlled trial of the antigonadotropin danazol in painful nodular benign breast disease.Lancet. 1982 Apr 24;1(8278):928-30.

Dhar A, Srivastava A. Role of Centchroman in Regression of Mastalgia and Fibroadenoma. World J Surg (2007) 31:1178–1184

Tejwani PL, Srivastava A, Nerkar H, Dhar A, Hari S, Thulkar S, Chumber S, Kumar S. Centchroman Regresses Mastalgia: A Randomized Comparison with Danazol. Indian J Surg (May–June 2011) 73(3):199–205

Bansal V, Bansal A, Bansal AK. Efficacy of Sevista (Ormeloxifene) in treatment of mastalgia and fibrocystic breast disease:Int J Reprod Contracept Obstet Gynecol. 2015 Aug;4(4):1057-1060

Sandeep Kumar, Ruchi Rai, G.G. Agarwal, Varsha Dwivedi, Surender Kumar, Vinita Das. A randomized, double-blind, placebo-controlled trial of ormeloxifene in breast pain and nodularity: Natl Med J India 2013;26:69–74


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