Dr. Navanil Roy, Dr. Chaitanya S. Kulkarni


The prevalence of stone disease in India is 11%. Adult men are 3 times more affected than women. Kidney stone disease is a major
cause of morbidity in mankind. The metabolic defects are less likely to occur in the first time than recurrent stone formers. The
present study was aimed determine the urinary levels of calcium, uric acid and creatinine. Calcium and creatinine ratio and uric
acid and creatinine ratio was determined to screen patients with hypercalciuria and hyperuricosuria also find out recurrent stone
formers. In our research work we took 30 clinically diagnosed cases of urolithiasis and 30 age and sex matched healthy controls.
Our results showed increased concentration of stone promoters such as calcium & uric acid; and decreased concentration of stone
inhibitors such as creatinine in urine of urolithiasis patients. Observations of our research work provide some evidence regarding
the role of the above mentioned ratios in the pathogenesis of urolithiasis.


Metabolic Defects, Calcium/creatinine Ratio, Uric Acid/creatinine Ratio, Urolithiasis Patients

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