A STUDY OF CORRELATION BETWEEN SERUM URIC ACID AND EJECTION FRACTION IN HEART FAILURE PATIENTS

Dr S. Kondal Reddy, Dr. Vijaya

Abstract


BACKGROUND:Heart failure (HF) is a clinical syndrome that occurs in patients who, because of an inherited or acquired
abnormality of cardiac structure and or function.30%of elderly between 70-80 years develop heart failure.Hence there is a need
for a biomarker which is cheap. In a developing country like India where uric acid evaluation can be done in rural set up at the cost
of about Rs 50, the present study aims at establishing the evaluation of uric acid levels in heart failure.
Methods:This obsevational study was conducted in a tertiary care hospial in Hyderabad.100 patients admitted with symptoms
and signs of Heart Failure.Baseline clinical examination,ECG,2DECHO were performed and if tested positive were evaluated for
serum uric acid levels along with blood counts,biochemistries, serum electrolytes,cardiac enzymes. Levels of uric acid were
compared with LVEF (Left Ventricular Ejection Fraction) to asses its prognostic significance and also with functional NYHA class.
Results: The mean age of study population was 47.3 ± 13.4. 24 % patients each were present in the age group of, 51 60 yrs 41
50 yrs and 31 40 yrs respectively followed by 14 % patients in the age group of 61 70 yrs.47 % were males and 53 % were
females male : female ratio was 1.12:1.55% of males and 54%females had acute caronary syndrome as precipitating event. In
the present study the range of uric acid was observed between 7.1 10 mg/dl, the mean uric acid levels were observed to be 8.6 ±
0.67.There was a significant and inverse correlation observed between uric acid levels and ejection fraction r = -0.808 p <0.001
and positive correlation observed between NYHA class and uric acid levels r = 0.844, p <0.005.
Conclusions:Excessive uric acid levels in chronic heart failure has lead to the chronic inflammation thereby contributing to the
oxidative damage to the myocardium .In heart failure patients,with serum uric acid is more than 7 mg / dl, then either RWMA or
Global hypokinesia positive OR LVEF < 50%. Serum uric acid levels are more in the severe functional disability patients (NYH III
AND IV). In rural set up due to financial constraints uric acid levels can be used as a prognostic marker.


Keywords


biochemistries electrolytes enzymes prognostic significance

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References


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